The adoption of health information technology (HIT) reveals salient effects on improving the existing operational capabilities of healthcare organizations. One of the important roles of IT is to facilitate the formation of organizational capabilities and, in turn, sustainable competitive advantage in healthcare organizations. In particular, paying greater attention to suitability and capability of IT architecture within firms can directly address current and future business needs. Event-driven architecture (EDA) is one of the emerging IT that has been introduced for real-time enterprises. The software vendors increasingly design health information systems that follow EDA's design principles. Given such conditions, this study intends to contribute to the existing IS research on proposing (a) EDA capability and (b) specific EDA capabilities: sensing, responding, interoperability and flexibility capability and (c) a conceptual research model presenting the relationships among EDA capabilities, dynamic capability and competitive advantage.