Abstract
A current endeavor in research is the replacement of expensive and rare platinum group metal homogeneous catalysts with those of earth abundant metals such as iron, cobalt, nickel and zinc. In order for these cheaper metals to achieve comparable activity with conventional industrial catalysts, they must be activated by suitable ligands. These often offer a site of reactivity for substrate activation in addition to tuning the electronic properties of the metal and controlling the stereochemistry around the metal. Catalysis that is thought to exploit this extra point of reactivity at the ligand is termed metal-ligand bifunctional catalysis or metal-ligand cooperative catalysis. This chapter describes the design elements for ligands required to activate iron(II) so that the resulting complexes can serve for the first time as effective catalysts for the asymmetric reduction of ketones and imines, either by asymmetric transfer hydrogenation (ATH) from isopropanol solvent or asymmetric direct hydrogenation (ADH) using hydrogen gas.
| Original language | English (US) |
|---|---|
| Title of host publication | Ligand Design in Metal Chemistry |
| Subtitle of host publication | Reactivity and Catalysis |
| Publisher | wiley |
| Pages | 205-236 |
| Number of pages | 32 |
| ISBN (Electronic) | 9781118839621 |
| ISBN (Print) | 9781118839836 |
| DOIs | |
| State | Published - Sep 2 2016 |
| Externally published | Yes |
ASJC Scopus subject areas
- Chemistry(all)
Keywords
- Amine
- Asymmetric catalysis
- Green chemistry
- Hydride
- Hydrogenation
- Iron
- Ketone
- Phosphine