TY - JOUR
T1 - Linkage Disequilibrium Mapping of Schizophrenia Susceptibility to the CAPON Region of Chromosome 1q22
AU - Brzustowicz, Linda M.
AU - Simone, Jaime
AU - Mohseni, Paria
AU - Hayter, Jared E.
AU - Hodgkinson, Kathleen A.
AU - Chow, Eva W.C.
AU - Bassett, Anne S.
N1 - Funding Information: This work was supported by grant R01 MH62440 from the National Institutes of Mental Health (L.M.B.), the Canadian Institutes of Health Research (A.S.B.), and The Bill Jefferies Schizophrenia Endowment Fund (A.S.B.). Genotyping services were provided by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through contract N01-HG-65403 from the National Institutes of Health to the Johns Hopkins University. Thanks to Christina Lucey and Vivian Wong for assistance with figure preparation and to Tero Hiekkalinna for assistance with PSEUDOMARKER.
PY - 2004/5
Y1 - 2004/5
N2 - Previously, we have reported linkage of markers from chromosome 1q22 to schizophrenia, a finding supported by several independent studies. We have now examined the region of strongest linkage for evidence of linkage disequilibrium (LD) in a sample of 24 Canadian familial-schizophrenia pedigrees. Analysis of 14 microsatellites and 15 single-nudeotide polymorphisms (SNPs) from the 5.4-Mb region between D1S1653 and D1S1677 produced significant evidence (nominal P<.05 of LD between schizophrenia and 2 microsatellites and 6 SNPs. All of the markers exhibiting significant LD to schizophrenia fall within the genomic extent of the gene for carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON), making it a prime positional candidate for the schizophrenia-susceptibility locus on 1q22, although initial mutation analysis of this gene has not identified any schizophrenia-associated changes within exons. Consistent with several recently identified candidate genes for schizophrenia, CAPON is involved in signal transduction in the NMDA receptor system, highlighting the potential importance of this pathway in the etiology of schizophrenia.
AB - Previously, we have reported linkage of markers from chromosome 1q22 to schizophrenia, a finding supported by several independent studies. We have now examined the region of strongest linkage for evidence of linkage disequilibrium (LD) in a sample of 24 Canadian familial-schizophrenia pedigrees. Analysis of 14 microsatellites and 15 single-nudeotide polymorphisms (SNPs) from the 5.4-Mb region between D1S1653 and D1S1677 produced significant evidence (nominal P<.05 of LD between schizophrenia and 2 microsatellites and 6 SNPs. All of the markers exhibiting significant LD to schizophrenia fall within the genomic extent of the gene for carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON), making it a prime positional candidate for the schizophrenia-susceptibility locus on 1q22, although initial mutation analysis of this gene has not identified any schizophrenia-associated changes within exons. Consistent with several recently identified candidate genes for schizophrenia, CAPON is involved in signal transduction in the NMDA receptor system, highlighting the potential importance of this pathway in the etiology of schizophrenia.
UR - https://www.scopus.com/pages/publications/2342625339
UR - https://www.scopus.com/pages/publications/2342625339#tab=citedBy
U2 - 10.1086/420774
DO - 10.1086/420774
M3 - Article
C2 - 15065015
SN - 0002-9297
VL - 74
SP - 1057
EP - 1063
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 5
ER -