Lipid Mediators and Lung Function

Barry Weinberger; Daniel Hirsch; Kingsley Yin; Bernd W. Spur

doi:https://doi.org/10.1016/B978-0-12-404577-4.00021-7

Lipid Mediators and Lung Function

Barry Weinberger, Daniel Hirsch, Kingsley Yin, Bernd W. Spur

Cell Biology

Rowan University

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Bioactive derivatives of polyunsaturated fatty acids (most importantly, arachidonic acid, EPA, and DHA) regulate essential aspects of lung function. These mediators include prostaglandins, isoprostanes, leukotrienes, lipoxins, and resolvins. They exert synergistic and opposing effects on bronchial constriction and relaxation, pulmonary vascular tone, and/or the initiation and cessation of immune and inflammatory responses in the lung. The identification in lung tissues of specific receptors for these mediators, as well as the lipid-responsive PPAR-α and PPAR-γ transcription factors, suggests that they are important in maintaining lung homeostasis. Several fatty acid-derived mediators (or their synthetic agonists or antagonists) have demonstrated therapeutic value in correcting derangements of lung function in asthma, pulmonary hypertension, inflammatory lung disease, fibrosis, or acute lung injury.

Original language	English (US)
Title of host publication	Comparative Biology of the Normal Lung
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	403-421
Number of pages	19
ISBN (Electronic)	9780124045774
ISBN (Print)	9780124047266
DOIs	https://doi.org/10.1016/B978-0-12-404577-4.00021-7
State	Published - Mar 18 2015

ASJC Scopus subject areas

Medicine(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

https://doi.org/10.1016/B978-0-12-404577-4.00021-7

Cite this

@inbook{e2a7b512f0864294a019d1114021058a,

title = "Lipid Mediators and Lung Function",

abstract = "Bioactive derivatives of polyunsaturated fatty acids (most importantly, arachidonic acid, EPA, and DHA) regulate essential aspects of lung function. These mediators include prostaglandins, isoprostanes, leukotrienes, lipoxins, and resolvins. They exert synergistic and opposing effects on bronchial constriction and relaxation, pulmonary vascular tone, and/or the initiation and cessation of immune and inflammatory responses in the lung. The identification in lung tissues of specific receptors for these mediators, as well as the lipid-responsive PPAR-α and PPAR-γ transcription factors, suggests that they are important in maintaining lung homeostasis. Several fatty acid-derived mediators (or their synthetic agonists or antagonists) have demonstrated therapeutic value in correcting derangements of lung function in asthma, pulmonary hypertension, inflammatory lung disease, fibrosis, or acute lung injury.",

author = "Barry Weinberger and Daniel Hirsch and Kingsley Yin and Spur, {Bernd W.}",

year = "2015",

month = mar,

day = "18",

doi = "https://doi.org/10.1016/B978-0-12-404577-4.00021-7",

language = "English (US)",

isbn = "9780124047266",

pages = "403--421",

booktitle = "Comparative Biology of the Normal Lung",

publisher = "Elsevier Inc.",

address = "United States",

}

TY - CHAP

T1 - Lipid Mediators and Lung Function

AU - Weinberger, Barry

AU - Hirsch, Daniel

AU - Yin, Kingsley

AU - Spur, Bernd W.

PY - 2015/3/18

Y1 - 2015/3/18

N2 - Bioactive derivatives of polyunsaturated fatty acids (most importantly, arachidonic acid, EPA, and DHA) regulate essential aspects of lung function. These mediators include prostaglandins, isoprostanes, leukotrienes, lipoxins, and resolvins. They exert synergistic and opposing effects on bronchial constriction and relaxation, pulmonary vascular tone, and/or the initiation and cessation of immune and inflammatory responses in the lung. The identification in lung tissues of specific receptors for these mediators, as well as the lipid-responsive PPAR-α and PPAR-γ transcription factors, suggests that they are important in maintaining lung homeostasis. Several fatty acid-derived mediators (or their synthetic agonists or antagonists) have demonstrated therapeutic value in correcting derangements of lung function in asthma, pulmonary hypertension, inflammatory lung disease, fibrosis, or acute lung injury.

AB - Bioactive derivatives of polyunsaturated fatty acids (most importantly, arachidonic acid, EPA, and DHA) regulate essential aspects of lung function. These mediators include prostaglandins, isoprostanes, leukotrienes, lipoxins, and resolvins. They exert synergistic and opposing effects on bronchial constriction and relaxation, pulmonary vascular tone, and/or the initiation and cessation of immune and inflammatory responses in the lung. The identification in lung tissues of specific receptors for these mediators, as well as the lipid-responsive PPAR-α and PPAR-γ transcription factors, suggests that they are important in maintaining lung homeostasis. Several fatty acid-derived mediators (or their synthetic agonists or antagonists) have demonstrated therapeutic value in correcting derangements of lung function in asthma, pulmonary hypertension, inflammatory lung disease, fibrosis, or acute lung injury.

UR - http://www.scopus.com/inward/record.url?scp=84939611834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939611834&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/B978-0-12-404577-4.00021-7

DO - https://doi.org/10.1016/B978-0-12-404577-4.00021-7

M3 - Chapter

SN - 9780124047266

SP - 403

EP - 421

BT - Comparative Biology of the Normal Lung

PB - Elsevier Inc.

ER -

Lipid Mediators and Lung Function

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this