Localized tacrolimus delivery for transplant rejection prevention via tyrosphere-loaded rapidly soluble films

Joseph Molde, Antonio Merolli, Joseph A.M. Steele, Mariana R.N. Lima, Alexandre G. Lellouch, Shannon G. Pratts, Curtis J. Cetrulo, Joachim Kohn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Advances in surgical techniques and immunology have enabled transplantation of composite tissue allografts (CTAs; e.g., upper extremity, face, genitourinary tissues) to treat complex soft tissue injuries and extremity amputations. However, >85% of transplant recipients develop at least one episode of rejection within the first year, and >50% experience multiple such episodes. Systemic distribution of orally or intravenously delivered immunosuppressants, such as tacrolimus, increases the likelihood of widespread side effects and is further dependent on patient compliance. To address these limitations, we have developed a nanosphere-based local drug delivery system using a biodegradable and bioresorbable tyrosine-derived nanospheres (TyroSpheres) [1] loaded in a water-soluble thin film. These films are designed to be implanted over the graft interface where they will rapidly dissolve, delivering tacrolimus-loaded TyroSpheres to the surrounding tissue and providing long-term, localized immunosuppression to reduce the incidence of rejection episodes.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Nanospheres
Graft Rejection
Tacrolimus
Tyrosine
Composite Tissue Allografts
Soft Tissue Injuries
Drug Delivery Systems
Immunosuppressive Agents
Patient Compliance
Allergy and Immunology
Amputation
Upper Extremity
Immunosuppression
Extremities
Transplantation
Transplants
Water
Incidence
Rejection (Psychology)

All Science Journal Classification (ASJC) codes

  • Materials Chemistry
  • Biophysics
  • Biochemistry
  • Biotechnology
  • Biomaterials

Cite this

Molde, J., Merolli, A., Steele, J. A. M., Lima, M. R. N., Lellouch, A. G., Pratts, S. G., ... Kohn, J. (2019). Localized tacrolimus delivery for transplant rejection prevention via tyrosphere-loaded rapidly soluble films. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Molde, Joseph ; Merolli, Antonio ; Steele, Joseph A.M. ; Lima, Mariana R.N. ; Lellouch, Alexandre G. ; Pratts, Shannon G. ; Cetrulo, Curtis J. ; Kohn, Joachim. / Localized tacrolimus delivery for transplant rejection prevention via tyrosphere-loaded rapidly soluble films. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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Molde, J, Merolli, A, Steele, JAM, Lima, MRN, Lellouch, AG, Pratts, SG, Cetrulo, CJ & Kohn, J 2019, Localized tacrolimus delivery for transplant rejection prevention via tyrosphere-loaded rapidly soluble films. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Localized tacrolimus delivery for transplant rejection prevention via tyrosphere-loaded rapidly soluble films. / Molde, Joseph; Merolli, Antonio; Steele, Joseph A.M.; Lima, Mariana R.N.; Lellouch, Alexandre G.; Pratts, Shannon G.; Cetrulo, Curtis J.; Kohn, Joachim.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Merolli, Antonio

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AU - Lellouch, Alexandre G.

AU - Pratts, Shannon G.

AU - Cetrulo, Curtis J.

AU - Kohn, Joachim

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N2 - Statement of Purpose: Advances in surgical techniques and immunology have enabled transplantation of composite tissue allografts (CTAs; e.g., upper extremity, face, genitourinary tissues) to treat complex soft tissue injuries and extremity amputations. However, >85% of transplant recipients develop at least one episode of rejection within the first year, and >50% experience multiple such episodes. Systemic distribution of orally or intravenously delivered immunosuppressants, such as tacrolimus, increases the likelihood of widespread side effects and is further dependent on patient compliance. To address these limitations, we have developed a nanosphere-based local drug delivery system using a biodegradable and bioresorbable tyrosine-derived nanospheres (TyroSpheres) [1] loaded in a water-soluble thin film. These films are designed to be implanted over the graft interface where they will rapidly dissolve, delivering tacrolimus-loaded TyroSpheres to the surrounding tissue and providing long-term, localized immunosuppression to reduce the incidence of rejection episodes.

AB - Statement of Purpose: Advances in surgical techniques and immunology have enabled transplantation of composite tissue allografts (CTAs; e.g., upper extremity, face, genitourinary tissues) to treat complex soft tissue injuries and extremity amputations. However, >85% of transplant recipients develop at least one episode of rejection within the first year, and >50% experience multiple such episodes. Systemic distribution of orally or intravenously delivered immunosuppressants, such as tacrolimus, increases the likelihood of widespread side effects and is further dependent on patient compliance. To address these limitations, we have developed a nanosphere-based local drug delivery system using a biodegradable and bioresorbable tyrosine-derived nanospheres (TyroSpheres) [1] loaded in a water-soluble thin film. These films are designed to be implanted over the graft interface where they will rapidly dissolve, delivering tacrolimus-loaded TyroSpheres to the surrounding tissue and providing long-term, localized immunosuppression to reduce the incidence of rejection episodes.

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M3 - Conference contribution

T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

BT - Society for Biomaterials Annual Meeting and Exposition 2019

PB - Society for Biomaterials

ER -

Molde J, Merolli A, Steele JAM, Lima MRN, Lellouch AG, Pratts SG et al. Localized tacrolimus delivery for transplant rejection prevention via tyrosphere-loaded rapidly soluble films. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).