TY - JOUR
T1 - Long-term amphetamine treatment decreases brain serotonin metabolism
T2 - Implications for theories of schizophrenia
AU - Trulson, Michael E.
AU - Jacobs, Barry L.
PY - 1979
Y1 - 1979
N2 - Long-term amphetamine administration to cats (a mean of 8.75 milligrams per kilogram twice daily for 10 days) produced large decreases (40 to 67 percent in serotonin and its major metabolite, 5-hydroxyindoleacetic acid, in all brain regions examined. This treatment also produced several behaviors that are dependent on depressed central serotonergic neurotransmission, and which normally are elicited exclusively by hallucinogenic drugs. Short-term amphetamine administration (15 mg/kg) did not produce these behaviors and resulted in small decreases in brain serotonin and no change in 5-hydroxyindoleacetic acid. These data are discussed in the context of monoamine theories of schizophrenia.
AB - Long-term amphetamine administration to cats (a mean of 8.75 milligrams per kilogram twice daily for 10 days) produced large decreases (40 to 67 percent in serotonin and its major metabolite, 5-hydroxyindoleacetic acid, in all brain regions examined. This treatment also produced several behaviors that are dependent on depressed central serotonergic neurotransmission, and which normally are elicited exclusively by hallucinogenic drugs. Short-term amphetamine administration (15 mg/kg) did not produce these behaviors and resulted in small decreases in brain serotonin and no change in 5-hydroxyindoleacetic acid. These data are discussed in the context of monoamine theories of schizophrenia.
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U2 - https://doi.org/10.1126/science.572992
DO - https://doi.org/10.1126/science.572992
M3 - Article
C2 - 572992
SN - 0036-8075
VL - 205
SP - 1295
EP - 1297
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
IS - 4412
ER -