Abstract
Microcins are a class of ribosomally synthesized antibacterial peptides produced by Enterobacteriaceae and active against closely related bacterial species. While some microcins are active as unmodified peptides, others are heavily modified by dedicated maturation enzymes. Low-molecular-weight microcins from the post-translationally modified group target essential molecular machines inside the cells. In this review, available structural and functional data about three such microcins - microcin J25, microcin B17 and microcin C7-C51 - are discussed. While all three low-molecular-weight post-translationally modified microcins are produced by Escherichia coli, inferences based on sequence and structural similarities with peptides encoded or produced by phylogenetically diverse bacteria are made whenever possible to put these compounds into a larger perspective.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1380-1394 |
| Number of pages | 15 |
| Journal | Molecular microbiology |
| Volume | 65 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 1 2007 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Microbiology
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Low-molecular-weight post-translationally modified microcins. / Severinov, Konstantin; Semenova, Ekaterina; Kazakov, Alexey; Kazakov, Teymur; Gelfand, Mikhail S.
In: Molecular microbiology, Vol. 65, No. 6, 01.09.2007, p. 1380-1394.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Low-molecular-weight post-translationally modified microcins
AU - Severinov, Konstantin
AU - Semenova, Ekaterina
AU - Kazakov, Alexey
AU - Kazakov, Teymur
AU - Gelfand, Mikhail S.
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Microcins are a class of ribosomally synthesized antibacterial peptides produced by Enterobacteriaceae and active against closely related bacterial species. While some microcins are active as unmodified peptides, others are heavily modified by dedicated maturation enzymes. Low-molecular-weight microcins from the post-translationally modified group target essential molecular machines inside the cells. In this review, available structural and functional data about three such microcins - microcin J25, microcin B17 and microcin C7-C51 - are discussed. While all three low-molecular-weight post-translationally modified microcins are produced by Escherichia coli, inferences based on sequence and structural similarities with peptides encoded or produced by phylogenetically diverse bacteria are made whenever possible to put these compounds into a larger perspective.
AB - Microcins are a class of ribosomally synthesized antibacterial peptides produced by Enterobacteriaceae and active against closely related bacterial species. While some microcins are active as unmodified peptides, others are heavily modified by dedicated maturation enzymes. Low-molecular-weight microcins from the post-translationally modified group target essential molecular machines inside the cells. In this review, available structural and functional data about three such microcins - microcin J25, microcin B17 and microcin C7-C51 - are discussed. While all three low-molecular-weight post-translationally modified microcins are produced by Escherichia coli, inferences based on sequence and structural similarities with peptides encoded or produced by phylogenetically diverse bacteria are made whenever possible to put these compounds into a larger perspective.
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UR - http://www.scopus.com/inward/citedby.url?scp=34548303828&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/j.1365-2958.2007.05874.x
DO - https://doi.org/10.1111/j.1365-2958.2007.05874.x
M3 - Short survey
C2 - 17711420
VL - 65
SP - 1380
EP - 1394
JO - Molecular Microbiology
JF - Molecular Microbiology
SN - 0950-382X
IS - 6
ER -