Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae

Yuqian Ma, Jin Bao, Yuanwei Zhang, Zhanjun Li, Xiangyu Zhou, Changlin Wan, Ling Huang, Yang Zhao, Gang Han, Tian Xue

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Mammals cannot see light over 700 nm in wavelength. This limitation is due to the physical thermodynamic properties of the photon-detecting opsins. However, the detection of naturally invisible near-infrared (NIR) light is a desirable ability. To break this limitation, we developed ocular injectable photoreceptor-binding upconversion nanoparticles (pbUCNPs). These nanoparticles anchored on retinal photoreceptors as miniature NIR light transducers to create NIR light image vision with negligible side effects. Based on single-photoreceptor recordings, electroretinograms, cortical recordings, and visual behavioral tests, we demonstrated that mice with these nanoantennae could not only perceive NIR light, but also see NIR light patterns. Excitingly, the injected mice were also able to differentiate sophisticated NIR shape patterns. Moreover, the NIR light pattern vision was ambient-daylight compatible and existed in parallel with native daylight vision. This new method will provide unmatched opportunities for a wide variety of emerging bio-integrated nanodevice designs and applications. Video Abstract: Injectable photoreceptor-binding nanoparticles with the ability to convert photons from low-energy to high-energy forms allow mice to develop infrared vision without compromising their normal vision and associated behavioral responses.

Original languageEnglish (US)
Pages (from-to)243-255.e15
JournalCell
Volume177
Issue number2
DOIs
StatePublished - Apr 4 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • biocompatibility
  • image vision
  • nanoantenna
  • near-infrared light
  • photoreceptors
  • retina
  • spectrum
  • upconversion nanoparticle
  • visual behavior
  • visual enhancement

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  • Cite this

    Ma, Y., Bao, J., Zhang, Y., Li, Z., Zhou, X., Wan, C., Huang, L., Zhao, Y., Han, G., & Xue, T. (2019). Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell, 177(2), 243-255.e15. https://doi.org/10.1016/j.cell.2019.01.038