TY - JOUR
T1 - Maturation of auditory evoked potentials from 6 to 48 months
T2 - Prediction to 3 and 4 year language and cognitive abilities
AU - Choudhury, Naseem
AU - Benasich, April A.
N1 - Funding Information: This research was supported by a grant from the Charles A. Dana Foundation and the Elizabeth H. Solomon Center for Neurodevelopmental Research . We thank the parents and children who participated in this study, and Cecylia Chojnowska and Teresa Realpe-Bonilla for technical and editorial support.
PY - 2011/2
Y1 - 2011/2
N2 - Objective: To investigate the maturation of long-latency auditory evoked potentials (LLAEP) from 6 to 48. months in infants with a family history of language impairment (FH+) and control infants (FH-). Methods: LLAEPs of seventeen FH+ infants were compared to 28 FH- infants at 6, 9, 12, 16, 24, 36 and 48. months. Participants received a passive oddball paradigm using fast- and slow-rate non-linguistic auditory stimuli and at 36 and 48. months completed a battery of standardized language and cognitive tests. Results: Overall, the morphology of LLAEP responses differed for fast- versus slow-rate stimuli. Significant age-related changes in latency and amplitude were observed. Group differences, favoring FH- infants, in the rate of maturation of LLAEPs were found. Responses to fast-rate stimuli predicted language abilities at 36 and 48. months of age. Conclusions: The development of LLAEP in FH+ children is modulated by differences in the rate of maturation as well as variations in temporal processing abilities. Significance: These findings provide evidence for the role of non-linguistic auditory processes in early language development and illustrate the utility of using a perceptual-processing skills model to further our understanding of the precursors of language development and impairment.
AB - Objective: To investigate the maturation of long-latency auditory evoked potentials (LLAEP) from 6 to 48. months in infants with a family history of language impairment (FH+) and control infants (FH-). Methods: LLAEPs of seventeen FH+ infants were compared to 28 FH- infants at 6, 9, 12, 16, 24, 36 and 48. months. Participants received a passive oddball paradigm using fast- and slow-rate non-linguistic auditory stimuli and at 36 and 48. months completed a battery of standardized language and cognitive tests. Results: Overall, the morphology of LLAEP responses differed for fast- versus slow-rate stimuli. Significant age-related changes in latency and amplitude were observed. Group differences, favoring FH- infants, in the rate of maturation of LLAEPs were found. Responses to fast-rate stimuli predicted language abilities at 36 and 48. months of age. Conclusions: The development of LLAEP in FH+ children is modulated by differences in the rate of maturation as well as variations in temporal processing abilities. Significance: These findings provide evidence for the role of non-linguistic auditory processes in early language development and illustrate the utility of using a perceptual-processing skills model to further our understanding of the precursors of language development and impairment.
KW - Language impairment
KW - Maturation of infant LLAEP
UR - http://www.scopus.com/inward/record.url?scp=78149357352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78149357352&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2010.05.035
DO - 10.1016/j.clinph.2010.05.035
M3 - Article
C2 - 20685161
SN - 1388-2457
VL - 122
SP - 320
EP - 338
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 2
ER -