Measles on the edge

Coastal heterogeneities and infection dynamics

Nita Bharti, Yingcun Xia, Ottar N. Bjornstad, Bryan T. Grenfell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mathematical models can help elucidate the spatio-temporal dynamics of epidemics as well as the impact of control measures. The gravity model for directly transmitted diseases is currently one of the most parsimonious models for spatial epidermic spread. This model uses distance-weighted, population size-dependent coupling to estimate host movement and disease incidence in metapopulations. The model captures overall measles dynamics in terms of underlying human movement in pre-vaccination England and Wales (previously established). In spatial models, edges often present a special challenge. Therefore, to test the model's robustness, we analyzed gravity model incidence predictions for coast cities in England and Wales. Results show that, although predictions are accurae for inland towns, they significantly underestimate coastal presistence. We examine incidence, outbreak seasonality, and public transportation records, to show that the model's inaccuracies stern from an underestimation of total contacts per individual along the coast. We rescue this predicted 'edge effect' by increasing coastal contacts to approximate the number of per capita inland contacts. These result illustrate the impact of 'edge effects' on epidemic metapopulations in general and illustrate directions for the refinement of spatiotemporal epidemic models.

Original languageEnglish (US)
Article numbere1941
JournalPLoS ONE
Volume3
Issue number4
DOIs
StatePublished - Apr 9 2008
Externally publishedYes

Fingerprint

Measles
Wales
Gravitation
England
Incidence
Infection
Population Density
Disease Outbreaks
Vaccination
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bharti, Nita ; Xia, Yingcun ; Bjornstad, Ottar N. ; Grenfell, Bryan T. / Measles on the edge : Coastal heterogeneities and infection dynamics. In: PLoS ONE. 2008 ; Vol. 3, No. 4.
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Measles on the edge : Coastal heterogeneities and infection dynamics. / Bharti, Nita; Xia, Yingcun; Bjornstad, Ottar N.; Grenfell, Bryan T.

In: PLoS ONE, Vol. 3, No. 4, e1941, 09.04.2008.

Research output: Contribution to journalArticle

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AU - Bharti, Nita

AU - Xia, Yingcun

AU - Bjornstad, Ottar N.

AU - Grenfell, Bryan T.

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