TY - GEN
T1 - Mechanical enhancement of a tissue-engineered scaffold for bone regeneration
AU - Patel, Pushpendra
AU - Taylor, Brittany
AU - Freeman, Joseph
N1 - Publisher Copyright: © 2014 IEEE.
PY - 2014/12/2
Y1 - 2014/12/2
N2 - With over 600,000 patients suffering from bone deficiencies annually in the United States, bone regeneration has come to the forefront of medical research. Current repair treatments utilize autografts (transplanting a patient's own bone from one site to another) and allografts (tissue donated from a cadaver) to treat extensive bone fractures. Although the autograft is the benchmark treatment, both autografts and allografts have their drawbacks such as donor site morbidity and disease transmission, respectively. As a result, alternative treatment methods including tissue-engineered solutions are being explored to potentially circumvent these disadvantages. The Musculoskeletal Tissue Regeneration laboratory has previously created a composite trabecular and cortical biomimetic synthetic bone scaffold, which mimics the architecture of native bone. However, the compressive strength of the current cortical scaffold does not match that of native bone. This study specifically focuses on the incorporation of sintered hydroxyapatite (HAP) columns to enhance the mechanical properties of these scaffolds, particularly under compressive loads. The integration of mechanically enhanced HAP columns serves as a promising step towards developing one of the first biomimetic bone scaffolds that exhibits the mechanical properties of native bone, while simultaneously promoting osteoblastic and vascular differentiation.
AB - With over 600,000 patients suffering from bone deficiencies annually in the United States, bone regeneration has come to the forefront of medical research. Current repair treatments utilize autografts (transplanting a patient's own bone from one site to another) and allografts (tissue donated from a cadaver) to treat extensive bone fractures. Although the autograft is the benchmark treatment, both autografts and allografts have their drawbacks such as donor site morbidity and disease transmission, respectively. As a result, alternative treatment methods including tissue-engineered solutions are being explored to potentially circumvent these disadvantages. The Musculoskeletal Tissue Regeneration laboratory has previously created a composite trabecular and cortical biomimetic synthetic bone scaffold, which mimics the architecture of native bone. However, the compressive strength of the current cortical scaffold does not match that of native bone. This study specifically focuses on the incorporation of sintered hydroxyapatite (HAP) columns to enhance the mechanical properties of these scaffolds, particularly under compressive loads. The integration of mechanically enhanced HAP columns serves as a promising step towards developing one of the first biomimetic bone scaffolds that exhibits the mechanical properties of native bone, while simultaneously promoting osteoblastic and vascular differentiation.
KW - bone regeneration
KW - hydroxyapatite
KW - load-bearing scaffold
UR - https://www.scopus.com/pages/publications/84940702168
UR - https://www.scopus.com/pages/publications/84940702168#tab=citedBy
U2 - 10.1109/NEBEC.2014.6972901
DO - 10.1109/NEBEC.2014.6972901
M3 - Conference contribution
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
BT - Proceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
Y2 - 25 April 2014 through 27 April 2014
ER -