Mechanisms of neurotransmitter release

TY - JOUR

T1 - Mechanisms of neurotransmitter release

AU - Hsu, S. C.

AU - Ting, A. E.

AU - Hazuka, C. D.

AU - Davanger, S.

AU - Kennev, J. W.

AU - Kee, Y.

AU - Scheller, R. H.

PY - 1997

Y1 - 1997

N2 - rsec6 and rsecS are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8 15 complex which is essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with a combined molecular weight of 743 kDa. The complex is broadly expressed in brain and displays a plasma membrane localization in nerve terminals. Membrane associated rsec6/8 complex coimmunoprecipitates with syntaxin, a plasma membrane protein critical for neurotransmission. These data suggest a role for the mammalian rsec6/8 complex in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus.

AB - rsec6 and rsecS are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8 15 complex which is essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with a combined molecular weight of 743 kDa. The complex is broadly expressed in brain and displays a plasma membrane localization in nerve terminals. Membrane associated rsec6/8 complex coimmunoprecipitates with syntaxin, a plasma membrane protein critical for neurotransmission. These data suggest a role for the mammalian rsec6/8 complex in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus.

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M3 - Article

SN - 0892-6638

VL - 11

SP - A1447

JO - FASEB Journal

JF - FASEB Journal

IS - 9

ER -