Mechanisms of Pavlovian fear conditioning: Has the engram been located?

TY - JOUR

T1 - Mechanisms of Pavlovian fear conditioning

T2 - Has the engram been located?

AU - Paré, Denis

PY - 2002/9/1

Y1 - 2002/9/1

N2 - Uncertainty persists as to whether the amygdala is a crucial site of plasticity for classically conditioned fear or merely a sensory relay to structures generating fear responses. A recent Nature study suggests that associative synaptic changes take place in neurons of the amygdala during fear conditioning, and that these changes require dopamine-mediated modulation. Nevertheless, these findings do not prove that the amygdala is a sufficient site of plasticity for fear memory.

AB - Uncertainty persists as to whether the amygdala is a crucial site of plasticity for classically conditioned fear or merely a sensory relay to structures generating fear responses. A recent Nature study suggests that associative synaptic changes take place in neurons of the amygdala during fear conditioning, and that these changes require dopamine-mediated modulation. Nevertheless, these findings do not prove that the amygdala is a sufficient site of plasticity for fear memory.

UR - https://www.scopus.com/pages/publications/0036753151

UR - https://www.scopus.com/pages/publications/0036753151#tab=citedBy

U2 - 10.1016/S0166-2236(02)02243-9

DO - 10.1016/S0166-2236(02)02243-9

M3 - Review article

C2 - 12183195

SN - 0166-2236

VL - 25

SP - 436

EP - 437

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 9

ER -