Meta-Analysis of Usefulness of Treatment of Hypercholesterolemia With Statins for Primary Prevention in Patients Older Than 75 Years

John B. Kostis, Michail Giakoumis, Stavros Zinonos, Javier Cabrera, William J. Kostis

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Clinical guidelines from the United States and Europe do not recommend treatment with statins for primary prevention in patients with hypercholesterolemia who are older than 75 years. Data from 35 randomized controlled trials in this age group where statin therapy for primary prevention was compared with placebo or usual care were analyzed. Using all-cause death as the outcome, we performed 2 types of analyses: frequentist and Bayesian. Frequentist analysis indicated no significant difference in mortality between cases (on statins) and controls (on placebo or usual care, p = 0.16). However, in the Bayesian analysis, patients >75 years had lower mortality from treatment with statins (p = 0.03). In conclusion, Bayesian analysis indicates a definite, statistically significant and clinically relevant benefit of statin treatment for primary prevention in patients >75 years of age.

Original languageEnglish (US)
Pages (from-to)1154-1157
Number of pages4
JournalAmerican Journal of Cardiology
Volume125
Issue number8
DOIs
StatePublished - Apr 15 2020

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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