Metabolic regulation of angiogenesis in diabetes and aging

Naoki Sawada, Zolt Arany

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Impaired angiogenesis and endothelial dysfunction are hallmarks of diabetes and aging. Clinical efforts at promoting angiogenesis have largely focused on growth factor pathways, with mixed results. Recently, a new repertoire of endothelial intracellular molecules critical to endothelial metabolism has emerged as playing an important role in regulating angiogenesis. This review thus focuses on the emerging importance and therapeutic potential of these proteins and of endothelial bioenergetics in diabetes and aging.

Original languageEnglish (US)
Pages (from-to)290-307
Number of pages18
JournalPhysiology
Volume32
Issue number4
DOIs
StatePublished - Jun 14 2017

All Science Journal Classification (ASJC) codes

  • Physiology

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