TY - JOUR
T1 - Microfabricated sieve for the continuous sorting of macromolecules
AU - Duke, T. A.J.
AU - Austin, R. H.
PY - 1998/2/16
Y1 - 1998/2/16
N2 - In a two-dimensional periodic but asymmetric environment, a Brownian particle that is driven in one direction by a potential gradient will also drift in the orthogonal direction at a rate that depends on its diffusion coefficient. On this basis, we propose a new method for separating biological macromolecules according to size. A fine stream of molecules is electrophoresed through a microfabricated sieve, etched from a silicon chip by lithography. The sieve consists of a periodic array of oblong obstacles, which deflect the molecules so that each species follows a different trajectory, oblique to the flow. Advantages promised by the technique include improved efficiency, continuous sorting and ready automation.
AB - In a two-dimensional periodic but asymmetric environment, a Brownian particle that is driven in one direction by a potential gradient will also drift in the orthogonal direction at a rate that depends on its diffusion coefficient. On this basis, we propose a new method for separating biological macromolecules according to size. A fine stream of molecules is electrophoresed through a microfabricated sieve, etched from a silicon chip by lithography. The sieve consists of a periodic array of oblong obstacles, which deflect the molecules so that each species follows a different trajectory, oblique to the flow. Advantages promised by the technique include improved efficiency, continuous sorting and ready automation.
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U2 - 10.1103/PhysRevLett.80.1552
DO - 10.1103/PhysRevLett.80.1552
M3 - Article
SN - 0031-9007
VL - 80
SP - 1552
EP - 1555
JO - Physical review letters
JF - Physical review letters
IS - 7
ER -