Modulation of HIV transmission by neisseria gonorrhoeae: Molecular and immunological aspects

TY - JOUR

T1 - Modulation of HIV transmission by neisseria gonorrhoeae

T2 - Molecular and immunological aspects

AU - Jarvis, Gary A.

AU - Chang, Theresa L.

PY - 2012/4

Y1 - 2012/4

N2 - Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in monocytes and modulate T cell activation. In vivo, an increase in the number of endocervical CD4+ T cells has been found in GC-infected women. Additionally, GC appears to modulate HIV-specific immune responses in HIV-exposed sex workers. Interestingly, in vitro, GC exhibits HIV enhancing or inhibitory effects depending on the HIV target cells. This review summarizes molecular and immunological aspects of the modulation of HIV infection and transmission by GC. Future studies using a multi-cellular system or in animal models will offer insight into the mechanisms by which GC increases HIV transmission.

AB - Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in monocytes and modulate T cell activation. In vivo, an increase in the number of endocervical CD4+ T cells has been found in GC-infected women. Additionally, GC appears to modulate HIV-specific immune responses in HIV-exposed sex workers. Interestingly, in vitro, GC exhibits HIV enhancing or inhibitory effects depending on the HIV target cells. This review summarizes molecular and immunological aspects of the modulation of HIV infection and transmission by GC. Future studies using a multi-cellular system or in animal models will offer insight into the mechanisms by which GC increases HIV transmission.

KW - GC-HIV co-infection

KW - HIV transmission

KW - Neisseria gonorrhoea

UR - https://www.scopus.com/pages/publications/84861118194

UR - https://www.scopus.com/pages/publications/84861118194#tab=citedBy

U2 - 10.2174/157016212800618138

DO - 10.2174/157016212800618138

M3 - Review article

C2 - 22384840

SN - 1570-162X

VL - 10

SP - 211

EP - 217

JO - Current HIV research

JF - Current HIV research

IS - 3

ER -