Molecular epidemiology of methicillin-resistant Staphylococcus aureus in 12 New York hospitals

Richard B. Roberts, Alexandre De Lencastre, William Eisner, Elena P. Severina, Bo Shopsin, Barry N. Kreiswirth, Alexander Tomasz

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

Consecutive single-patient methicillin-resistant Staphylococcus aureus (MRSA) isolates (270) from 12 hospitals (8217 beds) in metropolitan New York City were collected during May 1996. In 11 of 12 hospitals, MRSA was most frequent in the general medical services. DNA typing ('fingerprinting') revealed that mecA:Tn554:PFGE (pulsed-field gel electrophoresis) type I:A:A accounted for 113 (42%) of 270 isolates, was detected in all hospitals, and was the predominant clone in 9. Thirteen of 15 I:E:F isolates were from 1 hospital, and the remaining 2 were from another hospital of the same health system. Type V:NH:E was isolated from 22 (79%) of the 28 patients with AIDS, including 8 of 9 patients from an additional hospital. Subtype V:NH:E2 was recovered from 11 patients, 9 of whom had AIDS, including all 5 AIDS patients from one floor of a nursing home affiliated with a third hospital. By using both mecA:Tn554 probes and PFGE, MRSA clusters and outbreaks may be detected and provide a rationale for appropriate infection control intervention.

Original languageEnglish (US)
Pages (from-to)164-171
Number of pages8
JournalJournal of Infectious Diseases
Volume178
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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