MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors

Liling Wan, Xin Lu, Salina Yuan, Yong Wei, Feng Guo, Minhong Shen, Min Yuan, Rumela Chakrabarti, Yuling Hua, Heath A. Smith, Mario Andres Blanco, Marina Chekmareva, Hao Wu, Roderick T. Bronson, Bruce Haffty, Yongna Xing, Yibin Kang

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The Metadherin gene (MTDH) is prevalently amplified in breast cancer and associated with poor prognosis; however, its functional contribution to tumorigenesis is poorly understood. Using mouse models representing different subtypes of breast cancer, we demonstrated that MTDH plays a critical role in mammary tumorigenesis by regulating oncogene-induced expansion and activities of tumor-initiating cells (TICs), whereas it is largely dispensable for normal development. Mechanistically, MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing Staphylococcal nuclease domain-containing 1 (SND1). Silencing MTDH or SND1 individually or disrupting their interaction compromises tumorigenenic potential of TICs invivo. This functional significance of MTDH-SND1 interaction is further supported by clinical analysis of human breast cancer samples.

Original languageEnglish (US)
Pages (from-to)92-105
Number of pages14
JournalCancer Cell
Volume26
Issue number1
DOIs
StatePublished - Jul 14 2014

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Micrococcal Nuclease
Neoplastic Stem Cells
Oncogenes
Carcinogens
Breast Neoplasms
Genes
Carcinogenesis
Breast
Gene Silencing
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research
  • Cell Biology

Cite this

Wan, Liling ; Lu, Xin ; Yuan, Salina ; Wei, Yong ; Guo, Feng ; Shen, Minhong ; Yuan, Min ; Chakrabarti, Rumela ; Hua, Yuling ; Smith, Heath A. ; Blanco, Mario Andres ; Chekmareva, Marina ; Wu, Hao ; Bronson, Roderick T. ; Haffty, Bruce ; Xing, Yongna ; Kang, Yibin. / MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors. In: Cancer Cell. 2014 ; Vol. 26, No. 1. pp. 92-105.
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abstract = "The Metadherin gene (MTDH) is prevalently amplified in breast cancer and associated with poor prognosis; however, its functional contribution to tumorigenesis is poorly understood. Using mouse models representing different subtypes of breast cancer, we demonstrated that MTDH plays a critical role in mammary tumorigenesis by regulating oncogene-induced expansion and activities of tumor-initiating cells (TICs), whereas it is largely dispensable for normal development. Mechanistically, MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing Staphylococcal nuclease domain-containing 1 (SND1). Silencing MTDH or SND1 individually or disrupting their interaction compromises tumorigenenic potential of TICs invivo. This functional significance of MTDH-SND1 interaction is further supported by clinical analysis of human breast cancer samples.",
author = "Liling Wan and Xin Lu and Salina Yuan and Yong Wei and Feng Guo and Minhong Shen and Min Yuan and Rumela Chakrabarti and Yuling Hua and Smith, {Heath A.} and Blanco, {Mario Andres} and Marina Chekmareva and Hao Wu and Bronson, {Roderick T.} and Bruce Haffty and Yongna Xing and Yibin Kang",
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Wan, L, Lu, X, Yuan, S, Wei, Y, Guo, F, Shen, M, Yuan, M, Chakrabarti, R, Hua, Y, Smith, HA, Blanco, MA, Chekmareva, M, Wu, H, Bronson, RT, Haffty, B, Xing, Y & Kang, Y 2014, 'MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors', Cancer Cell, vol. 26, no. 1, pp. 92-105. https://doi.org/10.1016/j.ccr.2014.04.027

MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors. / Wan, Liling; Lu, Xin; Yuan, Salina; Wei, Yong; Guo, Feng; Shen, Minhong; Yuan, Min; Chakrabarti, Rumela; Hua, Yuling; Smith, Heath A.; Blanco, Mario Andres; Chekmareva, Marina; Wu, Hao; Bronson, Roderick T.; Haffty, Bruce; Xing, Yongna; Kang, Yibin.

In: Cancer Cell, Vol. 26, No. 1, 14.07.2014, p. 92-105.

Research output: Contribution to journalArticle

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AU - Wan, Liling

AU - Lu, Xin

AU - Yuan, Salina

AU - Wei, Yong

AU - Guo, Feng

AU - Shen, Minhong

AU - Yuan, Min

AU - Chakrabarti, Rumela

AU - Hua, Yuling

AU - Smith, Heath A.

AU - Blanco, Mario Andres

AU - Chekmareva, Marina

AU - Wu, Hao

AU - Bronson, Roderick T.

AU - Haffty, Bruce

AU - Xing, Yongna

AU - Kang, Yibin

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