Mucopurulent cervicitis as a predictor of chlamydial infection and adverse pregnancy outcome

The investigators of the johns hopkins study of cervicitis and adverse pregnancy outcome

Research output: Contribution to journalArticle

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Abstract

The role of mucopurulent cervicitis in identifying pregnant women with Chlamydia trachomatis infection and poor pregnancy outcome was examined at the Johns Hopkins Hospital Obstetric Clinic in Baltimore, Maryland. The women studied were at high risk for chlamydial infection (14%), low birth-weight (12%), and preterm delivery (13%). Yellow endocervical discharge on a cotton swab had a sensitivity of 23.9%, specificity of 89.4%, and positive predictive value of 28.6% for predicting chlamydial infection. The presence of ⩾ 30 polymorphonuclear cells per 1000× field had a sensitivity of 25.0%, specificity of 87.6% and positive predictive value of 24.3%. Women with cervicitis defined by ⩾30 polymorphonuclear cells per 1000× field were twice as likely to deliver a low-birthweight infant. Adjustment for potential confounding variables did not explain this association. The poor sensitivity, specificity, and positive predictive value of mucopurulent cervicitis suggests that this parameter is not a useful screening tool for chlamydial infection in pregnant women. However, mucopurulent cervicitis may be an indicator of increased risk for poor pregnancy outcome.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalSexually transmitted diseases
Volume19
Issue number4
DOIs
StatePublished - Jan 1 1992

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Uterine Cervicitis
Pregnancy Outcome
Infection
Sensitivity and Specificity
Pregnant Women
Baltimore
Chlamydia Infections
Confounding Factors (Epidemiology)
Chlamydia trachomatis
Low Birth Weight Infant
Obstetrics

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases
  • Dermatology

Cite this

The investigators of the johns hopkins study of cervicitis and adverse pregnancy outcome (1992). Mucopurulent cervicitis as a predictor of chlamydial infection and adverse pregnancy outcome. Sexually transmitted diseases, 19(4), 198-202. https://doi.org/10.1097/00007435-199207000-00003
The investigators of the johns hopkins study of cervicitis and adverse pregnancy outcome. / Mucopurulent cervicitis as a predictor of chlamydial infection and adverse pregnancy outcome. In: Sexually transmitted diseases. 1992 ; Vol. 19, No. 4. pp. 198-202.
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The investigators of the johns hopkins study of cervicitis and adverse pregnancy outcome 1992, 'Mucopurulent cervicitis as a predictor of chlamydial infection and adverse pregnancy outcome', Sexually transmitted diseases, vol. 19, no. 4, pp. 198-202. https://doi.org/10.1097/00007435-199207000-00003

Mucopurulent cervicitis as a predictor of chlamydial infection and adverse pregnancy outcome. / The investigators of the johns hopkins study of cervicitis and adverse pregnancy outcome.

In: Sexually transmitted diseases, Vol. 19, No. 4, 01.01.1992, p. 198-202.

Research output: Contribution to journalArticle

TY - JOUR

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AU - The investigators of the johns hopkins study of cervicitis and adverse pregnancy outcome

AU - Nugent, Robert P.

AU - Hillier, Sharon L.

AU - Polk, B. Frank

AU - Berlin, Linda

AU - Kanchanaraksa, Sukon

AU - Munoz, Alvaro

AU - Kramer, Florence

AU - Spence, Michael

AU - Hoffman, Gary

AU - Winn, Kevin

AU - Repke, John

AU - Jones, M. Douglas

AU - Bartlett, John

AU - Bartlett, John

AU - Laughon, Barbara

AU - Bobo, Linda

AU - Horn, Janet

AU - Kappus, Beth

AU - Mattern, C. F.T.

AU - Brockman, Mary

AU - Donohue, Pam

AU - Lievers, Valerie

AU - Wheeler, Jean

AU - Nugent, Robert

AU - Rhoads, George

PY - 1992/1/1

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N2 - The role of mucopurulent cervicitis in identifying pregnant women with Chlamydia trachomatis infection and poor pregnancy outcome was examined at the Johns Hopkins Hospital Obstetric Clinic in Baltimore, Maryland. The women studied were at high risk for chlamydial infection (14%), low birth-weight (12%), and preterm delivery (13%). Yellow endocervical discharge on a cotton swab had a sensitivity of 23.9%, specificity of 89.4%, and positive predictive value of 28.6% for predicting chlamydial infection. The presence of ⩾ 30 polymorphonuclear cells per 1000× field had a sensitivity of 25.0%, specificity of 87.6% and positive predictive value of 24.3%. Women with cervicitis defined by ⩾30 polymorphonuclear cells per 1000× field were twice as likely to deliver a low-birthweight infant. Adjustment for potential confounding variables did not explain this association. The poor sensitivity, specificity, and positive predictive value of mucopurulent cervicitis suggests that this parameter is not a useful screening tool for chlamydial infection in pregnant women. However, mucopurulent cervicitis may be an indicator of increased risk for poor pregnancy outcome.

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The investigators of the johns hopkins study of cervicitis and adverse pregnancy outcome. Mucopurulent cervicitis as a predictor of chlamydial infection and adverse pregnancy outcome. Sexually transmitted diseases. 1992 Jan 1;19(4):198-202. https://doi.org/10.1097/00007435-199207000-00003