Multiple deoxyribonuclease activities in nuclei of HeLa cells

Judy R. Churchill, Jan Urbanczyk, George P. Studzinski

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Extracts of purified HeLa nuclei contain DNase activities which can be separated by CM-Sephadex column chromatography into four distinct enzymes. These DNases differ in their resistance to thermal inactivation and relative activity on different substrates. Each of these DNases can increase the template-primer activity of native DNA for DNA polymerase action.

Original languageEnglish (US)
Pages (from-to)1009-1016
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume53
Issue number3
DOIs
StatePublished - Aug 6 1973
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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