Murine survival of lethal irradiation with the use of human umbilical cord blood

Norman Ende; Nicholas M. Ponzio; Raghbir S. Athwal; Milton Ende; Dennis C. Giuliani

doi:https://doi.org/10.1016/0024-3205(92)90013-F

Murine survival of lethal irradiation with the use of human umbilical cord blood

Norman Ende, Nicholas M. Ponzio, Raghbir S. Athwal, Milton Ende, Dennis C. Giuliani

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent (70%) of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.

Original language	English (US)
Pages (from-to)	1249-1253
Number of pages	5
Journal	Life Sciences
Volume	51
Issue number	16
DOIs	https://doi.org/10.1016/0024-3205(92)90013-F
State	Published - 1992

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Murine survival of lethal irradiation with the use of human umbilical cord blood",

abstract = "We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent (70%) of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.",

author = "Norman Ende and Ponzio, {Nicholas M.} and Athwal, {Raghbir S.} and Milton Ende and Giuliani, {Dennis C.}",

note = "Funding Information: Supported in part by the Abraham S. Ende Research Foundation",

year = "1992",

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T1 - Murine survival of lethal irradiation with the use of human umbilical cord blood

AU - Ende, Norman

AU - Ponzio, Nicholas M.

AU - Athwal, Raghbir S.

AU - Ende, Milton

AU - Giuliani, Dennis C.

N1 - Funding Information: Supported in part by the Abraham S. Ende Research Foundation

PY - 1992

Y1 - 1992

N2 - We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent (70%) of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.

AB - We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent (70%) of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.

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Murine survival of lethal irradiation with the use of human umbilical cord blood

Abstract

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