Murine survival of lethal irradiation with the use of human umbilical cord blood

Norman Ende, Nicholas M. Ponzio, Raghbir S. Athwal, Milton Ende, Dennis C. Giuliani

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent (70%) of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.

Original languageEnglish (US)
Pages (from-to)1249-1253
Number of pages5
JournalLife Sciences
Issue number16
StatePublished - 1992

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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