Muscarinic control of long-range GABAergic inhibition within the rhinal cortices

John Apergis-Schoute, Aline Pinto, Denis Pare

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The perirhinal cortex plays a critical role in memory formation, in part because it forms reciprocal connections with the neocortex and entorhinal cortex and is thus in a position to integrate and transfer higher-order information to and from the hippocampus. However, for reasons that remain unclear, perirhinal transfer of neocortical inputs to the entorhinal cortex occurs with a low probability. Using patch recordings in vitro and tract-tracing combined with GAD-67 immunohistochemistry, we show that the perirhinal cortex contains GABAergic neurons with long-range projections to superficial entorhinal cells. This finding challenges the traditional model of cortical inhibition in which all trans-areal inhibition is thought to be disynaptic because the axons of GABAergic interneurons are assumed to be confined within the area in which their somata are located. Moreover, consistent with recent studies indicating that the formation of perirhinal-dependent memories requires activation of muscarinic receptors, long-range IPSPs were presynaptically inhibited by M2 receptor activation. Overall, these results suggest that long-range feedforward inhibition regulates perirhinal transfer of neocortical inputs to the entorhinal cortex, but that cholinergic inputs can presynaptically adjust the impact of this control mechanism as a function of environmental contingencies.

Original languageEnglish (US)
Pages (from-to)4061-4071
Number of pages11
JournalJournal of Neuroscience
Volume27
Issue number15
DOIs
StatePublished - Apr 11 2007

Fingerprint

Entorhinal Cortex
Nose
Cholinergic Agents
GABAergic Neurons
Inhibitory Postsynaptic Potentials
Neocortex
Carisoprodol
Muscarinic Receptors
Interneurons
Axons
Hippocampus
Immunohistochemistry
Inhibition (Psychology)
Transfer (Psychology)
Perirhinal Cortex

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Entorhinal
  • Hippocampus
  • Inhibition
  • Interneurons
  • Learning
  • Memory
  • Perirhinal

Cite this

Apergis-Schoute, John ; Pinto, Aline ; Pare, Denis. / Muscarinic control of long-range GABAergic inhibition within the rhinal cortices. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 15. pp. 4061-4071.
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Muscarinic control of long-range GABAergic inhibition within the rhinal cortices. / Apergis-Schoute, John; Pinto, Aline; Pare, Denis.

In: Journal of Neuroscience, Vol. 27, No. 15, 11.04.2007, p. 4061-4071.

Research output: Contribution to journalArticle

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