Mutational patterns correlate with genome organization in SARS and other coronaviruses

Research output: Contribution to journalShort surveypeer-review

13 Scopus citations


Focused efforts by several international laboratories have resulted in the sequencing of the genome of the causative agent of severe acute respiratory syndrome (SARS), novel coronavirus SARS-CoV, in record time. Using cumulative skew diagrams, I found that mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle. These findings might be relevant for the development of sequence-based diagnostics and the design of agents to treat SARS.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalTrends in Genetics
Issue number3
StatePublished - Mar 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics


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