Mutations compensating for the fitness cost of rifampicin resistance in Escherichia coli exert pleiotropic effect on RNA polymerase catalysis

Keyphrases

• Escherichia Coli 100%
• RNA-dependent RNA Polymerase (RdRP) 100%
• Rifampicin Resistance 100%
• Fitness Cost 100%
• Pleiotropic Effects 100%
• Compensatory mutation 66%
• Secondary mutation 66%
• Drug-resistant Bacteria 33%
• Evolutionary Process 33%
• Compensatory Mechanisms 33%
• Drug Use 33%
• Virulence 33%
• Growth Defects 33%
• Molecular Modeling 33%
• Drug Resistance 33%
• Rifampicin 33%
• Antibiotics 33%
• Transcription Machinery 33%
• Transcription Elongation 33%
• Resistance mutations 33%
• Biochemical Indices 33%
• Medical Problems 33%
• Cellular RNA 33%
• Bacterial Drug Resistance 33%
• Substrate Loading 33%
• Elongation Rate 33%
• Fitness Evaluation 33%
• Load Transfer 33%
• Relative Growth Rate 33%
• Treatment of Bacterial Infections 33%
• RNA Polymerase Gene 33%
• Fitness Loss 33%
• Bacterial Fitness 33%
• Structural Index 33%
• Broad-spectrum Drug 33%
• Nucleotidyl Transfer 33%
• Compensatory Substitutions 33%
• Transcriptional Regulatory Mechanism 33%

Immunology and Microbiology

• RNA Polymerase 100%
• Escherichia coli 100%
• Pleiotropy 100%
• Bacterium 50%
• Promoter Region 25%
• Molecular Model 25%
• Drug Resistance 25%
• Infectious Disease 25%
• Structural Gene 25%
• Antimicrobial Agent 25%
• Infection 25%
• Antibiotic Resistance 25%

Biochemistry, Genetics and Molecular Biology

• Escherichia coli 100%
• RNA Polymerase 100%
• Pleiotropy 100%
• Bacterium 50%
• Transcription 25%
• Promoter Region 25%
• Molecular Model 25%
• Drug Resistance 25%
• Antibiotic Resistance 25%
• Structural Gene 25%