Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family

Mina Ebrahimi-Rad, Pablo Bifani, Carlos Martin, Kristin Kremer, Sofia Samper, Jean Rauzier, Barry Kreiswirth, Jesus Blazquez, Marc Jouan, Dick Van Soolingen, Brigitte Gicquel

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201 Scopus citations

Abstract

Alterations in genes involved in the repair of DNA mutations (mut genes) result in an increased mutation frequency and better adaptability of the bacterium to stressful conditions. W-Beijing genotype strains displayed unique missense alterations in three putative mut genes, including two of the mutt type (Rv3908 and mutT2) and ogt. These polymorphisms were found to be characteristic and unique to W-Beijing phylogenetic lineage. Analysis of the mut genes in 55 representative W-Beijing isolates suggests a sequential acquisition of the mutations, elucidating a plausible pathway of the molecular evolution of this clonal family. The acquisition of mut genes may explain in part the ability of the isolates of W-Beijing type to rapidly adapt to their environment.

Original languageEnglish (US)
Pages (from-to)838-845
Number of pages8
JournalEmerging Infectious Diseases
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2003

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

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    Ebrahimi-Rad, M., Bifani, P., Martin, C., Kremer, K., Samper, S., Rauzier, J., Kreiswirth, B., Blazquez, J., Jouan, M., Van Soolingen, D., & Gicquel, B. (2003). Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family. Emerging Infectious Diseases, 9(7), 838-845. https://doi.org/10.3201/eid0907.020803