Nasal mucosal cells in human immunodeficiency virus type 1-seropositive patients with sinusitis

Ronald B. Moss; Thomas A. Scott; Michael Goldrich; Michelle Pitale; Anne Daniel; Robert Lebovics; Robert Walker; Yasu Igarashi; Michael A. Kaliner

doi:10.1002/(sici)1098-2825(1996)10:6

Nasal mucosal cells in human immunodeficiency virus type 1-seropositive patients with sinusitis

Ronald B. Moss
, Thomas A. Scott
, Michael Goldrich
, Michelle Pitale
, Anne Daniel
, Robert Lebovics
, Robert Walker
, Yasu Igarashi
, Michael A. Kaliner

School of Medicine

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, sinusitis has been recognized as a frequent clinical problem in human immunodeficiency virus (HIV-1)-infected individuals. We hypothesized that quantitative defects in immune cells in the nasal mucosa of HIV-positive subjects might mirror those in the peripheral blood and explain a predisposition to sinus disease in this population. Nasal mucosa biopsies were obtained from three different groups of patients-HIV-1 seropositive with sinusitis, HIV-1 seronegative with sinusitis, and HIV-1 seronegative without sinusitis (normal volunteer)-and phenotyped for cluster of differentiation antigen (CD) markers. In this study, we found patients with HIV-1 and sinus disease to have significantly lower numbers of both CD3 and CD4 nasal mucosa lymphocytes than seronegative controls in the nasal mucosa (P<0.05, P<0.01, respectively). A correlation between nasal mucosal CD4 cells and peripheral- blood CD4 cells was noted (R = 0.67, P ≤ 0.01). No deficiency in the number of nasal mucosa T or TC type mast cells was noted for the HIV-1-positive sinusitis group. Further study is warranted to define more completely the pathophysiology and microbiology of, and therapy for, this important clinical problem.

Original language	English
Pages (from-to)	418-422
Number of pages	5
Journal	Journal of Clinical Laboratory Analysis
Volume	10
Issue number	6
DOIs	https://doi.org/10.1002/(sici)1098-2825(1996)10:6
State	Published - 1996

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Immunology and Allergy
Hematology
Public Health, Environmental and Occupational Health
Clinical Biochemistry
Medical Laboratory Technology
Biochemistry, medical
Microbiology (medical)

Keywords

AIDS
CD4 cells
mast cells
opportunistic infections
tissue phenotyping
upper airway

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10.1002/(sici)1098-2825(1996)10:6

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title = "Nasal mucosal cells in human immunodeficiency virus type 1-seropositive patients with sinusitis",

abstract = "Recently, sinusitis has been recognized as a frequent clinical problem in human immunodeficiency virus (HIV-1)-infected individuals. We hypothesized that quantitative defects in immune cells in the nasal mucosa of HIV-positive subjects might mirror those in the peripheral blood and explain a predisposition to sinus disease in this population. Nasal mucosa biopsies were obtained from three different groups of patients-HIV-1 seropositive with sinusitis, HIV-1 seronegative with sinusitis, and HIV-1 seronegative without sinusitis (normal volunteer)-and phenotyped for cluster of differentiation antigen (CD) markers. In this study, we found patients with HIV-1 and sinus disease to have significantly lower numbers of both CD3 and CD4 nasal mucosa lymphocytes than seronegative controls in the nasal mucosa (P<0.05, P<0.01, respectively). A correlation between nasal mucosal CD4 cells and peripheral- blood CD4 cells was noted (R = 0.67, P ≤ 0.01). No deficiency in the number of nasal mucosa T or TC type mast cells was noted for the HIV-1-positive sinusitis group. Further study is warranted to define more completely the pathophysiology and microbiology of, and therapy for, this important clinical problem.",

keywords = "AIDS, CD4 cells, mast cells, opportunistic infections, tissue phenotyping, upper airway",

author = "Moss, \{Ronald B.\} and Scott, \{Thomas A.\} and Michael Goldrich and Michelle Pitale and Anne Daniel and Robert Lebovics and Robert Walker and Yasu Igarashi and Kaliner, \{Michael A.\}",

year = "1996",

doi = "10.1002/(sici)1098-2825(1996)10:6",

language = "English",

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pages = "418--422",

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T1 - Nasal mucosal cells in human immunodeficiency virus type 1-seropositive patients with sinusitis

AU - Moss, Ronald B.

AU - Scott, Thomas A.

AU - Goldrich, Michael

AU - Pitale, Michelle

AU - Daniel, Anne

AU - Lebovics, Robert

AU - Walker, Robert

AU - Igarashi, Yasu

AU - Kaliner, Michael A.

PY - 1996

Y1 - 1996

N2 - Recently, sinusitis has been recognized as a frequent clinical problem in human immunodeficiency virus (HIV-1)-infected individuals. We hypothesized that quantitative defects in immune cells in the nasal mucosa of HIV-positive subjects might mirror those in the peripheral blood and explain a predisposition to sinus disease in this population. Nasal mucosa biopsies were obtained from three different groups of patients-HIV-1 seropositive with sinusitis, HIV-1 seronegative with sinusitis, and HIV-1 seronegative without sinusitis (normal volunteer)-and phenotyped for cluster of differentiation antigen (CD) markers. In this study, we found patients with HIV-1 and sinus disease to have significantly lower numbers of both CD3 and CD4 nasal mucosa lymphocytes than seronegative controls in the nasal mucosa (P<0.05, P<0.01, respectively). A correlation between nasal mucosal CD4 cells and peripheral- blood CD4 cells was noted (R = 0.67, P ≤ 0.01). No deficiency in the number of nasal mucosa T or TC type mast cells was noted for the HIV-1-positive sinusitis group. Further study is warranted to define more completely the pathophysiology and microbiology of, and therapy for, this important clinical problem.

AB - Recently, sinusitis has been recognized as a frequent clinical problem in human immunodeficiency virus (HIV-1)-infected individuals. We hypothesized that quantitative defects in immune cells in the nasal mucosa of HIV-positive subjects might mirror those in the peripheral blood and explain a predisposition to sinus disease in this population. Nasal mucosa biopsies were obtained from three different groups of patients-HIV-1 seropositive with sinusitis, HIV-1 seronegative with sinusitis, and HIV-1 seronegative without sinusitis (normal volunteer)-and phenotyped for cluster of differentiation antigen (CD) markers. In this study, we found patients with HIV-1 and sinus disease to have significantly lower numbers of both CD3 and CD4 nasal mucosa lymphocytes than seronegative controls in the nasal mucosa (P<0.05, P<0.01, respectively). A correlation between nasal mucosal CD4 cells and peripheral- blood CD4 cells was noted (R = 0.67, P ≤ 0.01). No deficiency in the number of nasal mucosa T or TC type mast cells was noted for the HIV-1-positive sinusitis group. Further study is warranted to define more completely the pathophysiology and microbiology of, and therapy for, this important clinical problem.

KW - AIDS

KW - CD4 cells

KW - mast cells

KW - opportunistic infections

KW - tissue phenotyping

KW - upper airway

UR - https://www.scopus.com/pages/publications/0029979721

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DO - 10.1002/(sici)1098-2825(1996)10:6

M3 - Article

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SN - 0887-8013

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JO - Journal of Clinical Laboratory Analysis

JF - Journal of Clinical Laboratory Analysis

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ER -

Nasal mucosal cells in human immunodeficiency virus type 1-seropositive patients with sinusitis

Abstract

UN SDGs

ASJC Scopus subject areas

Keywords

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