Necrotising fasciitis of upper and lower limb: A systematic review

Antonios G. Angoules, George Kontakis, Emanuel Drakoulakis, George Vrentzos, Mark Granick, Peter V. Giannoudis

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Necrotising fasciitis is a rapidly progressive, life threatening soft tissue infection. In a significant proportion of patients, the extremities are involved as a result of trauma, needle puncture or extravasation of drugs, often leading to limb loss and devastating disability. In this systematic review of necrotising fasciitis of the upper and lower extremities, we report on the clinical characteristics, the predisposing factors, the associated diseases, the pathogenic bacteria, the surgical treatment and the final outcome in terms of limb loss and mortality. Data for a total of 451 patients were analysed for each parameter of interest. A percentage of 22.3% of the reviewed patients underwent amputation or disarticulation of a limb following failure of multiple debridements to control infection and the mortality rate was estimated as high as 21.9%.

Original languageEnglish (US)
JournalInjury
Volume38
Issue number5 SUPPL.
DOIs
StatePublished - Dec 1 2007

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Necrotizing Fasciitis
Lower Extremity
Extremities
Disarticulation
Soft Tissue Infections
Mortality
Debridement
Infection Control
Amputation
Punctures
Causality
Needles
Bacteria
Wounds and Injuries
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Orthopedics and Sports Medicine

Cite this

Angoules, A. G., Kontakis, G., Drakoulakis, E., Vrentzos, G., Granick, M., & Giannoudis, P. V. (2007). Necrotising fasciitis of upper and lower limb: A systematic review. Injury, 38(5 SUPPL.). https://doi.org/10.1016/j.injury.2007.10.030
Angoules, Antonios G. ; Kontakis, George ; Drakoulakis, Emanuel ; Vrentzos, George ; Granick, Mark ; Giannoudis, Peter V. / Necrotising fasciitis of upper and lower limb : A systematic review. In: Injury. 2007 ; Vol. 38, No. 5 SUPPL.
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Angoules, AG, Kontakis, G, Drakoulakis, E, Vrentzos, G, Granick, M & Giannoudis, PV 2007, 'Necrotising fasciitis of upper and lower limb: A systematic review', Injury, vol. 38, no. 5 SUPPL.. https://doi.org/10.1016/j.injury.2007.10.030

Necrotising fasciitis of upper and lower limb : A systematic review. / Angoules, Antonios G.; Kontakis, George; Drakoulakis, Emanuel; Vrentzos, George; Granick, Mark; Giannoudis, Peter V.

In: Injury, Vol. 38, No. 5 SUPPL., 01.12.2007.

Research output: Contribution to journalArticle

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Angoules AG, Kontakis G, Drakoulakis E, Vrentzos G, Granick M, Giannoudis PV. Necrotising fasciitis of upper and lower limb: A systematic review. Injury. 2007 Dec 1;38(5 SUPPL.). https://doi.org/10.1016/j.injury.2007.10.030