Neuromuscular Specializations of the Human Hypopharyngeal Muscles

Mohammed Elrabie Ahmed Mohammed; Liancai Mu; Hesham Mostafa Abdelfattah

doi:10.1007/s00455-020-10212-0

Neuromuscular Specializations of the Human Hypopharyngeal Muscles

Mohammed Elrabie Ahmed Mohammed
, Liancai Mu
, Hesham Mostafa Abdelfattah

Center for Discovery and Innovation

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The hypopharyngeal muscles in humans play a vital role in swallowing, speech, and respiration. Increasing evidence indicates that these muscles are specialized to perform life-sustaining upper aerodigestive functions. This review aims to provide current knowledge regarding the key structural, physiological, and biochemical features of the hypopharyngeal muscles, including innervation, contractile properties, histochemistry, biochemical properties, myosin heavy chain (MyHC) expression and regulation, and age-related alterations. These would clarify the unique neuromuscular specializations of the human hypopharyngeal muscles for a better understanding of the functions and pathological conditions of the pharynx and for the development of novel therapies to treat related upper airway disorders.

Original language	English
Pages (from-to)	769-785
Number of pages	17
Journal	Dysphagia
Volume	36
Issue number	5
DOIs	https://doi.org/10.1007/s00455-020-10212-0
State	Published - Oct 2021

ASJC Scopus subject areas

Otorhinolaryngology
Gastroenterology
Speech and Hearing

Keywords

Hypopharyngeal muscles
Innervation
Muscle fiber types
Respiration
Speech
Swallowing
Upper airway disorders

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10.1007/s00455-020-10212-0

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title = "Neuromuscular Specializations of the Human Hypopharyngeal Muscles",

abstract = "The hypopharyngeal muscles in humans play a vital role in swallowing, speech, and respiration. Increasing evidence indicates that these muscles are specialized to perform life-sustaining upper aerodigestive functions. This review aims to provide current knowledge regarding the key structural, physiological, and biochemical features of the hypopharyngeal muscles, including innervation, contractile properties, histochemistry, biochemical properties, myosin heavy chain (MyHC) expression and regulation, and age-related alterations. These would clarify the unique neuromuscular specializations of the human hypopharyngeal muscles for a better understanding of the functions and pathological conditions of the pharynx and for the development of novel therapies to treat related upper airway disorders.",

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doi = "10.1007/s00455-020-10212-0",

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AU - Mu, Liancai

AU - Abdelfattah, Hesham Mostafa

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Y1 - 2021/10

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AB - The hypopharyngeal muscles in humans play a vital role in swallowing, speech, and respiration. Increasing evidence indicates that these muscles are specialized to perform life-sustaining upper aerodigestive functions. This review aims to provide current knowledge regarding the key structural, physiological, and biochemical features of the hypopharyngeal muscles, including innervation, contractile properties, histochemistry, biochemical properties, myosin heavy chain (MyHC) expression and regulation, and age-related alterations. These would clarify the unique neuromuscular specializations of the human hypopharyngeal muscles for a better understanding of the functions and pathological conditions of the pharynx and for the development of novel therapies to treat related upper airway disorders.

KW - Hypopharyngeal muscles

KW - Innervation

KW - Muscle fiber types

KW - Respiration

KW - Speech

KW - Swallowing

KW - Upper airway disorders

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DO - 10.1007/s00455-020-10212-0

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C2 - 33159539

SN - 0179-051X

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SP - 769

EP - 785

JO - Dysphagia

JF - Dysphagia

IS - 5

ER -

Neuromuscular Specializations of the Human Hypopharyngeal Muscles

Abstract

ASJC Scopus subject areas

Keywords

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