New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM)

Phyllis J. Kanki, Francis Barin, Souleyman M'Boup, Jonathan S. Allan, Jean Loup Romet-Lemonne, Richard Marlink, Mary Frances McLane, Tun Hou Lee, Brigitte Arbeille, Francois Denis, M. Essex

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Abstract

This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-III AGM) infecting apparently healthy people in Senegal, West Africa, and the isolation of virus from these individuals. Serum samples from selected healthy West African people showed unusual serologic profiles when tested with antigens of HTLV-III/LAV, the etiologic agent of AIDS, and of STLV-III AGM. The samples reacted strongly with all of the major viral antigens of STLV-IIIAGM but showed variable or no reactivity with the major viral antigens of HTLV-III/LAV by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A new human T-lymphotropic virus (HTLV-IV) isolated from these people was grown in vitro and shown to have retroviral type particles, growth characteristics, and major viral proteins similar to those ofthe STLV-III and HTLV-III/LAV group of retroviruses. The gp120/160, gp32, p64, p55, p53, p24, and p15 proteins precipitated were the same size as and reactive with STLV-IIIAGM proteins. The serologic data suggest that this virus shares more common epitopes with STLV-IIIAGM than with the prototype HTLV-III/LAV that infects people in the United States and Europe. Further study of this virus and of the origin of the HTLV-III/LAV group of viruses may expand our understanding of the human AIDS virus.

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalScience
Volume232
Issue number4747
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Retroviridae
Viruses
HIV
Cercopithecus aethiops
Viral Antigens
Simian Acquired Immunodeficiency Syndrome
HIV Antigens
Senegal
HIV-2
Western Africa
Viral Proteins
Sodium Dodecyl Sulfate
Epitopes
Polyacrylamide Gel Electrophoresis
Proteins
Growth
Serum

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kanki, P. J., Barin, F., M'Boup, S., Allan, J. S., Romet-Lemonne, J. L., Marlink, R., ... Essex, M. (1986). New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM). Science, 232(4747), 238-243. https://doi.org/10.1126/science.3006256
Kanki, Phyllis J. ; Barin, Francis ; M'Boup, Souleyman ; Allan, Jonathan S. ; Romet-Lemonne, Jean Loup ; Marlink, Richard ; McLane, Mary Frances ; Lee, Tun Hou ; Arbeille, Brigitte ; Denis, Francois ; Essex, M. / New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM). In: Science. 1986 ; Vol. 232, No. 4747. pp. 238-243.
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title = "New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM)",
abstract = "This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-III AGM) infecting apparently healthy people in Senegal, West Africa, and the isolation of virus from these individuals. Serum samples from selected healthy West African people showed unusual serologic profiles when tested with antigens of HTLV-III/LAV, the etiologic agent of AIDS, and of STLV-III AGM. The samples reacted strongly with all of the major viral antigens of STLV-IIIAGM but showed variable or no reactivity with the major viral antigens of HTLV-III/LAV by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A new human T-lymphotropic virus (HTLV-IV) isolated from these people was grown in vitro and shown to have retroviral type particles, growth characteristics, and major viral proteins similar to those ofthe STLV-III and HTLV-III/LAV group of retroviruses. The gp120/160, gp32, p64, p55, p53, p24, and p15 proteins precipitated were the same size as and reactive with STLV-IIIAGM proteins. The serologic data suggest that this virus shares more common epitopes with STLV-IIIAGM than with the prototype HTLV-III/LAV that infects people in the United States and Europe. Further study of this virus and of the origin of the HTLV-III/LAV group of viruses may expand our understanding of the human AIDS virus.",
author = "Kanki, {Phyllis J.} and Francis Barin and Souleyman M'Boup and Allan, {Jonathan S.} and Romet-Lemonne, {Jean Loup} and Richard Marlink and McLane, {Mary Frances} and Lee, {Tun Hou} and Brigitte Arbeille and Francois Denis and M. Essex",
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Kanki, PJ, Barin, F, M'Boup, S, Allan, JS, Romet-Lemonne, JL, Marlink, R, McLane, MF, Lee, TH, Arbeille, B, Denis, F & Essex, M 1986, 'New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM)', Science, vol. 232, no. 4747, pp. 238-243. https://doi.org/10.1126/science.3006256

New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM). / Kanki, Phyllis J.; Barin, Francis; M'Boup, Souleyman; Allan, Jonathan S.; Romet-Lemonne, Jean Loup; Marlink, Richard; McLane, Mary Frances; Lee, Tun Hou; Arbeille, Brigitte; Denis, Francois; Essex, M.

In: Science, Vol. 232, No. 4747, 01.01.1986, p. 238-243.

Research output: Contribution to journalArticle

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T1 - New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM)

AU - Kanki, Phyllis J.

AU - Barin, Francis

AU - M'Boup, Souleyman

AU - Allan, Jonathan S.

AU - Romet-Lemonne, Jean Loup

AU - Marlink, Richard

AU - McLane, Mary Frances

AU - Lee, Tun Hou

AU - Arbeille, Brigitte

AU - Denis, Francois

AU - Essex, M.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-III AGM) infecting apparently healthy people in Senegal, West Africa, and the isolation of virus from these individuals. Serum samples from selected healthy West African people showed unusual serologic profiles when tested with antigens of HTLV-III/LAV, the etiologic agent of AIDS, and of STLV-III AGM. The samples reacted strongly with all of the major viral antigens of STLV-IIIAGM but showed variable or no reactivity with the major viral antigens of HTLV-III/LAV by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A new human T-lymphotropic virus (HTLV-IV) isolated from these people was grown in vitro and shown to have retroviral type particles, growth characteristics, and major viral proteins similar to those ofthe STLV-III and HTLV-III/LAV group of retroviruses. The gp120/160, gp32, p64, p55, p53, p24, and p15 proteins precipitated were the same size as and reactive with STLV-IIIAGM proteins. The serologic data suggest that this virus shares more common epitopes with STLV-IIIAGM than with the prototype HTLV-III/LAV that infects people in the United States and Europe. Further study of this virus and of the origin of the HTLV-III/LAV group of viruses may expand our understanding of the human AIDS virus.

AB - This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-III AGM) infecting apparently healthy people in Senegal, West Africa, and the isolation of virus from these individuals. Serum samples from selected healthy West African people showed unusual serologic profiles when tested with antigens of HTLV-III/LAV, the etiologic agent of AIDS, and of STLV-III AGM. The samples reacted strongly with all of the major viral antigens of STLV-IIIAGM but showed variable or no reactivity with the major viral antigens of HTLV-III/LAV by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A new human T-lymphotropic virus (HTLV-IV) isolated from these people was grown in vitro and shown to have retroviral type particles, growth characteristics, and major viral proteins similar to those ofthe STLV-III and HTLV-III/LAV group of retroviruses. The gp120/160, gp32, p64, p55, p53, p24, and p15 proteins precipitated were the same size as and reactive with STLV-IIIAGM proteins. The serologic data suggest that this virus shares more common epitopes with STLV-IIIAGM than with the prototype HTLV-III/LAV that infects people in the United States and Europe. Further study of this virus and of the origin of the HTLV-III/LAV group of viruses may expand our understanding of the human AIDS virus.

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