Abstract
This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-III AGM) infecting apparently healthy people in Senegal, West Africa, and the isolation of virus from these individuals. Serum samples from selected healthy West African people showed unusual serologic profiles when tested with antigens of HTLV-III/LAV, the etiologic agent of AIDS, and of STLV-III AGM. The samples reacted strongly with all of the major viral antigens of STLV-IIIAGM but showed variable or no reactivity with the major viral antigens of HTLV-III/LAV by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A new human T-lymphotropic virus (HTLV-IV) isolated from these people was grown in vitro and shown to have retroviral type particles, growth characteristics, and major viral proteins similar to those ofthe STLV-III and HTLV-III/LAV group of retroviruses. The gp120/160, gp32, p64, p55, p53, p24, and p15 proteins precipitated were the same size as and reactive with STLV-IIIAGM proteins. The serologic data suggest that this virus shares more common epitopes with STLV-IIIAGM than with the prototype HTLV-III/LAV that infects people in the United States and Europe. Further study of this virus and of the origin of the HTLV-III/LAV group of viruses may expand our understanding of the human AIDS virus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 238-243 |
| Number of pages | 6 |
| Journal | Science |
| Volume | 232 |
| Issue number | 4747 |
| DOIs | |
| State | Published - Jan 1 1986 |
| Externally published | Yes |
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New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM). / Kanki, Phyllis J.; Barin, Francis; M'Boup, Souleyman; Allan, Jonathan S.; Romet-Lemonne, Jean Loup; Marlink, Richard; McLane, Mary Frances; Lee, Tun Hou; Arbeille, Brigitte; Denis, Francois; Essex, M.
In: Science, Vol. 232, No. 4747, 01.01.1986, p. 238-243.Research output: Contribution to journal › Article
TY - JOUR
T1 - New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM)
AU - Kanki, Phyllis J.
AU - Barin, Francis
AU - M'Boup, Souleyman
AU - Allan, Jonathan S.
AU - Romet-Lemonne, Jean Loup
AU - Marlink, Richard
AU - McLane, Mary Frances
AU - Lee, Tun Hou
AU - Arbeille, Brigitte
AU - Denis, Francois
AU - Essex, M.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-III AGM) infecting apparently healthy people in Senegal, West Africa, and the isolation of virus from these individuals. Serum samples from selected healthy West African people showed unusual serologic profiles when tested with antigens of HTLV-III/LAV, the etiologic agent of AIDS, and of STLV-III AGM. The samples reacted strongly with all of the major viral antigens of STLV-IIIAGM but showed variable or no reactivity with the major viral antigens of HTLV-III/LAV by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A new human T-lymphotropic virus (HTLV-IV) isolated from these people was grown in vitro and shown to have retroviral type particles, growth characteristics, and major viral proteins similar to those ofthe STLV-III and HTLV-III/LAV group of retroviruses. The gp120/160, gp32, p64, p55, p53, p24, and p15 proteins precipitated were the same size as and reactive with STLV-IIIAGM proteins. The serologic data suggest that this virus shares more common epitopes with STLV-IIIAGM than with the prototype HTLV-III/LAV that infects people in the United States and Europe. Further study of this virus and of the origin of the HTLV-III/LAV group of viruses may expand our understanding of the human AIDS virus.
AB - This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-III AGM) infecting apparently healthy people in Senegal, West Africa, and the isolation of virus from these individuals. Serum samples from selected healthy West African people showed unusual serologic profiles when tested with antigens of HTLV-III/LAV, the etiologic agent of AIDS, and of STLV-III AGM. The samples reacted strongly with all of the major viral antigens of STLV-IIIAGM but showed variable or no reactivity with the major viral antigens of HTLV-III/LAV by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A new human T-lymphotropic virus (HTLV-IV) isolated from these people was grown in vitro and shown to have retroviral type particles, growth characteristics, and major viral proteins similar to those ofthe STLV-III and HTLV-III/LAV group of retroviruses. The gp120/160, gp32, p64, p55, p53, p24, and p15 proteins precipitated were the same size as and reactive with STLV-IIIAGM proteins. The serologic data suggest that this virus shares more common epitopes with STLV-IIIAGM than with the prototype HTLV-III/LAV that infects people in the United States and Europe. Further study of this virus and of the origin of the HTLV-III/LAV group of viruses may expand our understanding of the human AIDS virus.
UR - http://www.scopus.com/inward/record.url?scp=0022449157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022449157&partnerID=8YFLogxK
U2 - https://doi.org/10.1126/science.3006256
DO - https://doi.org/10.1126/science.3006256
M3 - Article
C2 - 3006256
VL - 232
SP - 238
EP - 243
JO - Science
JF - Science
SN - 0036-8075
IS - 4747
ER -