Nir-mediated spatiotemporal control of stem cell fate using multifunctional upconversion nanoparticles

Yixiao Zhang, Ki Bum Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Spatial and temporal modulation of stem cell behaviors are of great significance in the field of stem cell biology and regenerative medicine. Due to intrinsic spatial and temporal resolution, light has been vastly involved to achieve stem cell behavioral control. Current UV-Vis based approaches are highly limited, due to non-specific absorption, poor tissue penetration and photo-toxicity. On the contrary, upconversion nanoparticles (UCNPs) have gathered growing attention for vast applications due to minimal tissue absorption, high penetration depth, and minimal photo-toxicity from near-infrared (NIR) excitations. Given the significance of spatial and temporal modulations of stem cell behaviors for regenerative and tissue engineering, a biocompatible NIR-mediated stem cell differentiation manipulation method is on demand.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages819
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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