Nitric oxide, an important regulator of perfusion-contraction matching in conscious pigs

Raymond K. Kudej, Song Jung Kim, You Tang Shen, John B. Jackson, Amelia B. Kudej, Gui Ping Yang, Sanford P. Bishop, Stephen F. Vatner

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We examined whether nitric oxide (NO) inhibition during moderate reduction in coronary blood flow (CBF) would affect perfusion-contraction matching. Coronary stenosis (CS) was induced in conscious pigs, which resulted in a stable 39 ± 1% reduction in CBF for 1.5 h. Ischemic zone wall thickening (IZWT) decreased by an average of 56 ± 2% during CS from 2.7 ± 0.2 mm. After reperfusion, myocardial stunning was observed, but this recovered without evidence of necrosis. After recovery and subsequent administration of systemic NO synthase inhibition (N(ω)-nitro-L-arginine, 25 mg · kg-1 · day-1 x 3 days), CS for 1.5 h reduced CBF similarly but decreased IZWT significantly more, P < 0.05, by 89 ± 5%. Myocardial stunning, i.e., the decrease in IZWT at 12 h post-CS, was more severe (-65 ± 5% vs. -21 ± 3%), P < 0.05. Furthermore, CS during NO synthase inhibition resulted in multifocal subendocardial areas of necrosis in the area at risk. These data suggest that in the intact, conscious pig, NO inhibition prevents perfusion-contraction matching, resulting in intensification of post-ischemic stunning and development of subendocardial necrosis.

Original languageEnglish (US)
Pages (from-to)H451-H456
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume279
Issue number1 48-1
DOIs
StatePublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

Keywords

  • Infarction
  • Ischemia
  • Myocardium
  • Stunning

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