Non-antigen signals for B-cell growth and differentiation to antibody secretion

Seth Lederman, Michael J. Yellin, Lori R. Covey, Aileen M. Cleary, Robin Callard, Leonard Chess

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Recently, significant progress had been made in understanding the T-B lymphocyte interactions that control humoral immunity. This review highlights experiments that demonstrate a central role for interactions between T-cell-B-cell-activating molecule (CD40 ligand) expressed on T cells and CD40 on B cells in B-cell activation and immunoglobulin isotype switching, both in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 1993

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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