Novel combination markers for predicting survival in patients with muscle invasive bladder cancer

USP18 and DGCR2

Ye Hwan Kim, Won Tae Kim, Pildu Jeong, Yun Sok Ha, Ho Won Kang, Seok Joong Yun, Sung Kwon Moon, Yung Hyun Choi, Isaac Kim, Wun Jae Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We performed gene expression profiling in bladder cancer patients to identify cancer-specific survival-related genes in muscle invasive bladder cancer (MIBC) patients. Sixty-two patients with MIBC were selected as the original cohort and another 118 MIBC patients were chosen as a validation cohort. The expression of USP18, DGCR2, and ZNF699 genes were measured and we analyzed the association between gene signatures and survival. USP18 and DGCR2, were significantly correlated to cancer-specific death (P=0.020, P=0.007, respectively). Cancer-specific survival in the low USP18 or DGCR2 expression group was significantly longer than the high expression group (P=0.018, P=0.006, respectively). In multivariate Cox regression analysis, a combination of USP18 and DGCR2 mRNA expression levels were significant risk factors for cancer-specific death (HR, 2.106; CI, 1.043-4.254, P=0.038). Overall survival and cancer-specific survival rates in the low-combination group were significantly longer than those in the high-expression group (P=0.001, both). In conclusion, decreased expressions of USP18 and DGCR2 were significantly associated with longer cancer-specific survival, and also the combination of two genes was correlated to a longer survival for MIBC patients. Thus, the combination of USP18 and DGCR2 expression was shown to be a reliable prognostic marker for cancer-specific survival in MIBC.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalJournal of Korean medical science
Volume29
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Urinary Bladder Neoplasms
Muscles
Survival
Neoplasms
Genes
Gene Expression Profiling
Survival Rate
Regression Analysis
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • DGCR2
  • Gene expression profiling
  • Human
  • Survival
  • USP18 protein
  • Urinary bladder neoplasms

Cite this

Kim, Ye Hwan ; Kim, Won Tae ; Jeong, Pildu ; Ha, Yun Sok ; Kang, Ho Won ; Yun, Seok Joong ; Moon, Sung Kwon ; Choi, Yung Hyun ; Kim, Isaac ; Kim, Wun Jae. / Novel combination markers for predicting survival in patients with muscle invasive bladder cancer : USP18 and DGCR2. In: Journal of Korean medical science. 2014 ; Vol. 29, No. 3. pp. 351-356.
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abstract = "We performed gene expression profiling in bladder cancer patients to identify cancer-specific survival-related genes in muscle invasive bladder cancer (MIBC) patients. Sixty-two patients with MIBC were selected as the original cohort and another 118 MIBC patients were chosen as a validation cohort. The expression of USP18, DGCR2, and ZNF699 genes were measured and we analyzed the association between gene signatures and survival. USP18 and DGCR2, were significantly correlated to cancer-specific death (P=0.020, P=0.007, respectively). Cancer-specific survival in the low USP18 or DGCR2 expression group was significantly longer than the high expression group (P=0.018, P=0.006, respectively). In multivariate Cox regression analysis, a combination of USP18 and DGCR2 mRNA expression levels were significant risk factors for cancer-specific death (HR, 2.106; CI, 1.043-4.254, P=0.038). Overall survival and cancer-specific survival rates in the low-combination group were significantly longer than those in the high-expression group (P=0.001, both). In conclusion, decreased expressions of USP18 and DGCR2 were significantly associated with longer cancer-specific survival, and also the combination of two genes was correlated to a longer survival for MIBC patients. Thus, the combination of USP18 and DGCR2 expression was shown to be a reliable prognostic marker for cancer-specific survival in MIBC.",
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Novel combination markers for predicting survival in patients with muscle invasive bladder cancer : USP18 and DGCR2. / Kim, Ye Hwan; Kim, Won Tae; Jeong, Pildu; Ha, Yun Sok; Kang, Ho Won; Yun, Seok Joong; Moon, Sung Kwon; Choi, Yung Hyun; Kim, Isaac; Kim, Wun Jae.

In: Journal of Korean medical science, Vol. 29, No. 3, 01.01.2014, p. 351-356.

Research output: Contribution to journalArticle

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AU - Kang, Ho Won

AU - Yun, Seok Joong

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