Novel constant current iontophoretic delivery of Metoprolol in spontaneously hypertensive rabbits

C. Carley-Zakzewski, J. K.J. Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A constant current pulsed DC iontophoretic drug delivery system has been developed and experimentally verified using the beta blocking agent Metoprolol. Past investigations of iontophoretically delivered Metoprolol did not find any significant change in cardiovascular parameters. A high-frequency constant current pulse was used to deliver Metoprolol transdermally to an established acute hypertensive animal model. The constant current pulsed DC mode iontophoretic delivery of Metoprolol successfully reduced both mean arterial pressure and pulse pressure in spontaneously hypertensive rabbits. The success of this iontophoretic procedure has been attributed to the characteristics of the applied pulse.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Pages1101-1102
Number of pages2
Editionpt 3
ISBN (Print)0879425598
StatePublished - 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 3

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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