Novel FKS mutations associated with echinocandin resistance in Candida species

Guillermo Garcia-Effron, Daniel Joseph Chua, Jon Rupert Tomada, Joseph DiPersio, David S. Perlin, Mahmoud Ghannoum, Hector Bonilla

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis. The first isolate emerged during echinocandin treatment, while the others emerged after the same treatment. These strains harbored an amino acid substitution in Fksp never linked before with reduced echinocandin susceptibility in C. tropicalis or in C. glabrata. The molecular mechanism of reduced susceptibility was confirmed using a 1,3-β-D-glucan synthase inhibition assay.

Original languageEnglish (US)
Pages (from-to)2225-2227
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number5
StatePublished - May 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology


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