Novel Monodisperse PEGtide Dendrons as Nanocarrier for Drug Delivery

Patrick Sinko (Inventor), Jieming Gao (Inventor)

Research output: Innovation

Abstract

Representative Structure of PEGtide Invention Summary: Dentrimers and dendrons have generated tremendous interest as nanocarriers for various drug delivery applications. Rutgers scientists have developed a series of novel monodisperse PEGtide dendrons with versatility to accommodate various drug delivery demands. PEGtide dendrons containing alternating discrete poly (ethylene glycol) (dPEG) and amino acid/peptide moieties defines a new family of dendrons with significantly improved safety, biocompatibility and purity compared to its peers. A tunable interior void size that can reaches 200nm enables PEGtide dendrons to accommodate larger agent (e.g. Nucleic acids and proteins), meeting the advanced requirements of drug delivery applications. PEGtide dendrons have a benefit of higher coupling efficiency, automation and ease of purification. Functionalization of PEGtide dendrons (e.g. Conjugation of receptor ligands) have proven their promising application in targeted therapies. Market Applications: Pharmaceutical formulation for: Antineoplastic agents Antiviral agent Anti-inflammatory agents Antimicrobial agents Antiretroviral agents Vaccine Diagnostic agents Advantages: Low cytotoxicity Easily functionalized for targeted therapy Modular design with high flexibility to accommodate various applications, such as delivery of small molecule drugs, vaccines, or oligonucleotides/siRNA High structural homogeneity Intellectual Property & Development Status: Issued patent. Available for licensing and/or research collaboration.
Original languageEnglish (US)
StatePublished - Jul 2018

Keywords

  • Diagnostic Imaging
  • Drug Delivery
  • Genetic Therapy
  • Therapeutics

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