Novel synthesis and functionalization of ortho-ortho disubstituted biphenyls and a highly condensed novel heterocycle using radical cyclization reaction

C. H. Wang; A. R. White; S. N. Schwartz; S. Alluri; T. M. Cattabiani; L. K. Zhang; T. M. Chan; A. V. Buevich; A. K. Ganguly

doi:10.1016/j.tet.2012.09.036

Novel synthesis and functionalization of ortho-ortho disubstituted biphenyls and a highly condensed novel heterocycle using radical cyclization reaction

C. H. Wang, A. R. White, S. N. Schwartz, S. Alluri, T. M. Cattabiani, L. K. Zhang, T. M. Chan, A. V. Buevich, A. K. Ganguly

Department of Chemistry and Chemical Biology

Stevens Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

This paper describes a novel synthetic route for the preparation of ortho-ortho disubstituted biphenyls and compounds possessing highly condensed ring system represented by structures X and Y, respectively. Several approaches, such as intermolecular Grubb's olefin metathesis, Heck and, Suzuki reactions were incorporated to functionalize the core structures of X and Y making it suitable for the preparation of a library of compounds.

Original language	English
Pages (from-to)	9750-9762
Number of pages	13
Journal	Tetrahedron
Volume	68
Issue number	47
DOIs	https://doi.org/10.1016/j.tet.2012.09.036
State	Published - Nov 25 2012

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Atropisomerism
Grubb's metathesis
Heck reaction
Radical cyclization
Suzuki reaction

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10.1016/j.tet.2012.09.036

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Wang, C. H., White, A. R., Schwartz, S. N., Alluri, S., Cattabiani, T. M., Zhang, L. K., Chan, T. M., Buevich, A. V., & Ganguly, A. K. (2012). Novel synthesis and functionalization of ortho-ortho disubstituted biphenyls and a highly condensed novel heterocycle using radical cyclization reaction. Tetrahedron, 68(47), 9750-9762. https://doi.org/10.1016/j.tet.2012.09.036

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abstract = "This paper describes a novel synthetic route for the preparation of ortho-ortho disubstituted biphenyls and compounds possessing highly condensed ring system represented by structures X and Y, respectively. Several approaches, such as intermolecular Grubb's olefin metathesis, Heck and, Suzuki reactions were incorporated to functionalize the core structures of X and Y making it suitable for the preparation of a library of compounds.",

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doi = "10.1016/j.tet.2012.09.036",

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AU - Wang, C. H.

AU - White, A. R.

AU - Schwartz, S. N.

AU - Alluri, S.

AU - Cattabiani, T. M.

AU - Zhang, L. K.

AU - Chan, T. M.

AU - Buevich, A. V.

AU - Ganguly, A. K.

PY - 2012/11/25

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N2 - This paper describes a novel synthetic route for the preparation of ortho-ortho disubstituted biphenyls and compounds possessing highly condensed ring system represented by structures X and Y, respectively. Several approaches, such as intermolecular Grubb's olefin metathesis, Heck and, Suzuki reactions were incorporated to functionalize the core structures of X and Y making it suitable for the preparation of a library of compounds.

AB - This paper describes a novel synthetic route for the preparation of ortho-ortho disubstituted biphenyls and compounds possessing highly condensed ring system represented by structures X and Y, respectively. Several approaches, such as intermolecular Grubb's olefin metathesis, Heck and, Suzuki reactions were incorporated to functionalize the core structures of X and Y making it suitable for the preparation of a library of compounds.

KW - Atropisomerism

KW - Grubb's metathesis

KW - Heck reaction

KW - Radical cyclization

KW - Suzuki reaction

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JO - Tetrahedron

JF - Tetrahedron

IS - 47

ER -

Novel synthesis and functionalization of ortho-ortho disubstituted biphenyls and a highly condensed novel heterocycle using radical cyclization reaction

Abstract

ASJC Scopus subject areas

Keywords

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