Nucleotide sequences within the cholera toxin operon

Maria L. Gennaro, Peter J. Greenaway

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Nucleotide sequences coding for the N- and C-terminus of the A subunit and the N-terminus of the B subunit of cholera toxin were determined. These results show that the genes for the A and B subunits overlap out of phase by one nucleotide and that each subunit is synthesised as a precursor molecule which is subsequently processed after translation. It is proposed that the synthesis of each subunit is regulated at the translational level. Considerable homology with the heat labile toxin genes of enteropathogenic E.coli was noted.

Original languageEnglish (US)
Pages (from-to)3855-3861
Number of pages7
JournalNucleic acids research
Volume11
Issue number12
DOIs
StatePublished - Jun 25 1983

All Science Journal Classification (ASJC) codes

  • Genetics

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