Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene

Gary A. Heiman, Ruth Ottman, Rachel J. Saunders-Pullman, Laurie J. Ozelius, Neil J. Risch, Susan B. Bressman

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are comorbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume144
Issue number3
DOIs
StatePublished - Apr 5 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Keywords

  • Dystonia
  • Obsessive-compulsive disorder
  • Pleiotropy
  • Psychiatric manifestations
  • Variable expressivity

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