Ontologies for proteomics: Towards a systematic definition of structure and function that scales to the genome level

Ning Lan, Gaetano T. Montelione, Mark Gerstein

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

A principal aim of post-genomic biology is elucidating the structures, functions and biochemical properties of all gene products in a genome. However, to adequately comprehend such a large amount of information we need new descriptions of proteins that scale to the genomic level. In short, we need a unified ontology for proteomics. Much progress has been made towards this end, including a variety of approaches to systematic structural and functional classification and initial work towards developing standardized, unified descriptions for protein properties. In relation to function, there is a particularly great diversity of approaches, involving placing a protein in structured hierarchies or more-generalized networks and a recent approach based on circumscribing a protein's function through systematic enumeration of molecular interactions.

Original languageEnglish (US)
Pages (from-to)44-54
Number of pages11
JournalCurrent Opinion in Chemical Biology
Volume7
Issue number1
DOIs
StatePublished - Feb 2003

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

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