Opposite responses in the striato-nigral substance P system to D1 and D2 receptor activation

Patricia K. Sonsalla, James W. Gibb, Glen R. Hanson

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The roles of different dopamine receptors in mediating the responses of the striato-nigral substance P (SP) feedback loop were investigated. Subacute treatment of rats with the D1 agonist, SK&F 38393, produced a significant decrease in SP content in the substantia nigra whereas treatment with the D2 agonist, RU 24926, elevated nigral SP concentrations. Consequently, the elevation in nigral SP content which occurs following treatment with methamphetamine is likely a D2-mediated event. This conclusion is supported by our observation that the D2 antagonist, sulpiride, totally blocked the methamphetamine effect. These findings suggest that D1 and D2 receptors mediate opposing influences on the SP feedback system.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalEuropean Journal of Pharmacology
Volume105
Issue number1-2
DOIs
StatePublished - Oct 1 1984

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Basal ganglia
  • D receptor
  • Methamphetamine
  • Substance P

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