Organization of intracellular calcium signals generated by inositol lipid-dependent hormones

Thomas A. Rooney, Andrew P. Thomas

Research output: Contribution to journalReview article

22 Scopus citations


Recent studies at the single cell level have demonstrated hitherto unsuspected complexities in the organization of intracellular Ca2+ homeostasis in both the temporal and spatial domains. Activation of receptors coupled to the phosphoinositide signalling system has been shown to generate [Ca2+]i oscillations in many cell types. These oscillations display diverse patterns, with variations in oscillation amplitude, latency and frequency which are often tissue and/or agonist dose specific. Furthermore, increases in [Ca2+]i can either occur uniformly or originate from a specific region and propagate throughout the cell in the form of a Ca2+ wave. The significance and underlying mechanisms responsible for these phenomena are discussed.

Original languageEnglish (US)
Pages (from-to)223-237
Number of pages15
JournalPharmacology and Therapeutics
Issue number3
StatePublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology

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