Oxidative stress early in pregnancy and pregnancy outcome

Thomas Stein, Theresa O. Scholl, Margaret D. Schluter, Maria J. Leskiw, Xinhua Chen, Bernd W. Spur, Ana Rodriguez

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

Original languageEnglish (US)
Pages (from-to)841-848
Number of pages8
JournalFree Radical Research
Volume42
Issue number10
DOIs
StatePublished - Nov 17 2008
Externally publishedYes

Fingerprint

Oxidative stress
Biomarkers
Pregnancy Outcome
Oxidative Stress
Pregnancy
Isoprostanes
Oxidation
Dinoprost
Pre-Eclampsia
Oxidants
Assays
Parturition
Lipids
Defects
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Stein, T., Scholl, T. O., Schluter, M. D., Leskiw, M. J., Chen, X., Spur, B. W., & Rodriguez, A. (2008). Oxidative stress early in pregnancy and pregnancy outcome. Free Radical Research, 42(10), 841-848. https://doi.org/10.1080/10715760802510069
Stein, Thomas ; Scholl, Theresa O. ; Schluter, Margaret D. ; Leskiw, Maria J. ; Chen, Xinhua ; Spur, Bernd W. ; Rodriguez, Ana. / Oxidative stress early in pregnancy and pregnancy outcome. In: Free Radical Research. 2008 ; Vol. 42, No. 10. pp. 841-848.
@article{3815fe2b5898445eb5356f5127a40a19,
title = "Oxidative stress early in pregnancy and pregnancy outcome",
abstract = "The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.",
author = "Thomas Stein and Scholl, {Theresa O.} and Schluter, {Margaret D.} and Leskiw, {Maria J.} and Xinhua Chen and Spur, {Bernd W.} and Ana Rodriguez",
year = "2008",
month = "11",
day = "17",
doi = "https://doi.org/10.1080/10715760802510069",
language = "English (US)",
volume = "42",
pages = "841--848",
journal = "Free Radical Research",
issn = "1071-5762",
publisher = "Informa Healthcare",
number = "10",

}

Stein, T, Scholl, TO, Schluter, MD, Leskiw, MJ, Chen, X, Spur, BW & Rodriguez, A 2008, 'Oxidative stress early in pregnancy and pregnancy outcome', Free Radical Research, vol. 42, no. 10, pp. 841-848. https://doi.org/10.1080/10715760802510069

Oxidative stress early in pregnancy and pregnancy outcome. / Stein, Thomas; Scholl, Theresa O.; Schluter, Margaret D.; Leskiw, Maria J.; Chen, Xinhua; Spur, Bernd W.; Rodriguez, Ana.

In: Free Radical Research, Vol. 42, No. 10, 17.11.2008, p. 841-848.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oxidative stress early in pregnancy and pregnancy outcome

AU - Stein, Thomas

AU - Scholl, Theresa O.

AU - Schluter, Margaret D.

AU - Leskiw, Maria J.

AU - Chen, Xinhua

AU - Spur, Bernd W.

AU - Rodriguez, Ana

PY - 2008/11/17

Y1 - 2008/11/17

N2 - The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

AB - The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2α (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

UR - http://www.scopus.com/inward/record.url?scp=55849149026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55849149026&partnerID=8YFLogxK

U2 - https://doi.org/10.1080/10715760802510069

DO - https://doi.org/10.1080/10715760802510069

M3 - Article

VL - 42

SP - 841

EP - 848

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 10

ER -