Packaging in dsRNA viruses

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

Several families of viruses have segmented genomes with 3-12 chromosomes. They are capable of packaging these segments in a precise manner so that each virus particle contains one each of the genomic segments. The Cystoviridae are a family of bacteriophages that contain three genomic segments of dsRNA. During infection, the virus produces empty dodecahedral core particles that have the ability to specifically package plus strand transcripts of the genomic segments. The program of packaging makes use of the conformational changes in the surface of the particle as each transcript is packaged. The particles have complexes of a hexameric NTPase that serve as motors to bring the transcripts into the particle, and they have polymerase molecules in the interior that synthesize minus and plus strand copies of the genomic segments.

Original languageEnglish (US)
Title of host publicationViral Molecular Machines
EditorsMichael Rossmann, Venigalla Rao
Pages601-608
Number of pages8
DOIs
StatePublished - Mar 19 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume726

Fingerprint

Product Packaging
Viruses
Cystoviridae
Packaging
Nucleoside-Triphosphatase
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 3
Virion
Bacteriophages
Genome
Chromosomes
Genes
Infection
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mindich, L. (2012). Packaging in dsRNA viruses. In M. Rossmann, & V. Rao (Eds.), Viral Molecular Machines (pp. 601-608). (Advances in Experimental Medicine and Biology; Vol. 726). https://doi.org/10.1007/978-1-4614-0980-9_26
Mindich, Leonard. / Packaging in dsRNA viruses. Viral Molecular Machines. editor / Michael Rossmann ; Venigalla Rao. 2012. pp. 601-608 (Advances in Experimental Medicine and Biology).
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Mindich, L 2012, Packaging in dsRNA viruses. in M Rossmann & V Rao (eds), Viral Molecular Machines. Advances in Experimental Medicine and Biology, vol. 726, pp. 601-608. https://doi.org/10.1007/978-1-4614-0980-9_26

Packaging in dsRNA viruses. / Mindich, Leonard.

Viral Molecular Machines. ed. / Michael Rossmann; Venigalla Rao. 2012. p. 601-608 (Advances in Experimental Medicine and Biology; Vol. 726).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Mindich L. Packaging in dsRNA viruses. In Rossmann M, Rao V, editors, Viral Molecular Machines. 2012. p. 601-608. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-0980-9_26