Paradoxical roles for programmed cell death signaling during viral infection of the central nervous system

Juan P. Angel; Brian P. Daniels

doi:10.1016/j.conb.2022.102629

Paradoxical roles for programmed cell death signaling during viral infection of the central nervous system

Juan P. Angel, Brian P. Daniels

School of Arts and Sciences, Center for Collaborative Neuroscience

Rutgers, The State University

Research output: Contribution to journal › Review article › peer-review

Abstract

Programmed cell death (PCD) is an essential mechanism of antimicrobial defense. Recent work has revealed an unexpected diversity in the types of PCD elicited during infection, as well as defined unique roles for different PCD modalities in shaping the immune response. Here, we review recent work describing unique ways in which PCD signaling operates within the infected central nervous system (CNS). These studies reveal striking complexity in the regulation of PCD signaling by CNS cells, including both protective and pathological outcomes in the control of infection. Studies defining the specialized molecular mechanisms shaping PCD responses in the CNS promise to yield much needed new insights into the pathogenesis of neuroinvasive viral infection, informing future therapeutic development.

Original language	English (US)
Article number	102629
Journal	Current Opinion in Neurobiology
Volume	77
DOIs	https://doi.org/10.1016/j.conb.2022.102629
State	Published - Dec 2022

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.conb.2022.102629

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title = "Paradoxical roles for programmed cell death signaling during viral infection of the central nervous system",

abstract = "Programmed cell death (PCD) is an essential mechanism of antimicrobial defense. Recent work has revealed an unexpected diversity in the types of PCD elicited during infection, as well as defined unique roles for different PCD modalities in shaping the immune response. Here, we review recent work describing unique ways in which PCD signaling operates within the infected central nervous system (CNS). These studies reveal striking complexity in the regulation of PCD signaling by CNS cells, including both protective and pathological outcomes in the control of infection. Studies defining the specialized molecular mechanisms shaping PCD responses in the CNS promise to yield much needed new insights into the pathogenesis of neuroinvasive viral infection, informing future therapeutic development.",

author = "Angel, {Juan P.} and Daniels, {Brian P.}",

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year = "2022",

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AU - Angel, Juan P.

AU - Daniels, Brian P.

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N2 - Programmed cell death (PCD) is an essential mechanism of antimicrobial defense. Recent work has revealed an unexpected diversity in the types of PCD elicited during infection, as well as defined unique roles for different PCD modalities in shaping the immune response. Here, we review recent work describing unique ways in which PCD signaling operates within the infected central nervous system (CNS). These studies reveal striking complexity in the regulation of PCD signaling by CNS cells, including both protective and pathological outcomes in the control of infection. Studies defining the specialized molecular mechanisms shaping PCD responses in the CNS promise to yield much needed new insights into the pathogenesis of neuroinvasive viral infection, informing future therapeutic development.

AB - Programmed cell death (PCD) is an essential mechanism of antimicrobial defense. Recent work has revealed an unexpected diversity in the types of PCD elicited during infection, as well as defined unique roles for different PCD modalities in shaping the immune response. Here, we review recent work describing unique ways in which PCD signaling operates within the infected central nervous system (CNS). These studies reveal striking complexity in the regulation of PCD signaling by CNS cells, including both protective and pathological outcomes in the control of infection. Studies defining the specialized molecular mechanisms shaping PCD responses in the CNS promise to yield much needed new insights into the pathogenesis of neuroinvasive viral infection, informing future therapeutic development.

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DO - 10.1016/j.conb.2022.102629

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JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

M1 - 102629

ER -

Paradoxical roles for programmed cell death signaling during viral infection of the central nervous system

Abstract

ASJC Scopus subject areas

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