Parents do matter: genomic imprinting and parental sex effects in neurological disorders

Sansnee Chatkupt, Michelle Antonowicz, William G. Johnson

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Genomic imprinting is a recently recognized phenomenon of differential expression of genetic material depending upon whether the genetic material has come from the male or female parent. This process of differential phenotypic expression involves mammalian development both in the normal and abnormal situations, resulting in parental sex effects. However, some parental sex effects may be due to other mechanisms such as mitochondrial inheritance. In the following article, evidence for genomic imprinting in experimental animals and in diseases are summarized. Relevant human neurological disorders manifesting parental sex effects discussed here include myotonic dystrophy, Huntington's disease, fragile X syndrome, spinocerebellar ataxia type 1, and neurofibromatosis type 1 and 2. A possible mechanism of imprinting involves the processes of methylation imprint and replication imprint. The knowledge of imprinting is helpful in clinical practice particularly in the areas of genetic counseling, prenatal diagnosis, and possible future gene therapy.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of the Neurological Sciences
Volume130
Issue number1
DOIs
StatePublished - May 1995

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neurology

Keywords

  • Genetic
  • Genome
  • Imprinting
  • Parental sex effects

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