Parkinson's disease-associated protein Parkin: An unusual player in cancer

Juan Liu, Cen Zhang, Wenwei Hu, Zhaohui Feng

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.

Original languageAmerican English
Article number40
JournalCancer Communications
Issue number1
StatePublished - Jun 26 2018

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


  • Cancer
  • E3 ubiquitin ligase
  • Parkin
  • Parkinson's disease
  • Tumor suppressor


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