Parkinson's disease-associated protein Parkin: An unusual player in cancer

Juan Liu, Cen Zhang, Wenwei Hu, Zhaohui Feng

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.

Original languageAmerican English
Article number40
JournalCancer Communications
Volume38
Issue number1
DOIs
StatePublished - Jun 26 2018

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Keywords

  • Cancer
  • E3 ubiquitin ligase
  • Parkin
  • Parkinson's disease
  • Tumor suppressor

Fingerprint

Dive into the research topics of 'Parkinson's disease-associated protein Parkin: An unusual player in cancer'. Together they form a unique fingerprint.

Cite this