Particle separation in microfluidic channels using flow rate control

Sung Yang, Jeffery D. Zahn

Research output: Contribution to journalConference articlepeer-review

6 Scopus citations

Abstract

Microfluidic devices for particle recovery are successfully developed by controlling flow rate ratios of two daughter channels. Devices are prepared by using conventional Polydimethylsiloxane (PDMS) replica molding technique. The flow rate ratios of two daughter channels are controlled by changing the flow resistance through changing the geometry of the downstream channels. The particle recovery studies are conducted using 16 μm-diameter green fluorescent particles and using 8-10 μm-diameter human C8161 melanoma cells. For the fluorescent particles, the particle recovery efficiencies are 87.2%, 95.7%, 100%, and 100% for 2.5:1, 4:1, 6:1, and 8:1 flow rate ratios, respectively. Also, for the human C8161 melanoma cells, the cell recovery efficiencies are 88.7%, 98.9%, 100%, and 100% for 2.5:1, 4:1, 6:1, and 8:1 flow rate ratios, respectively.

Original languageAmerican English
Article numberIMECE2004-60862
Pages (from-to)127-132
Number of pages6
JournalAmerican Society of Mechanical Engineers, Fluids Engineering Division (Publication) FED
Volume260
DOIs
StatePublished - 2004
Externally publishedYes
Event2004 ASME International Mechanical Engineering Congress and Exposition, IMECE 2004 - Anaheim, CA, United States
Duration: Nov 13 2004Nov 19 2004

ASJC Scopus subject areas

  • General Engineering

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