Passive administration of purified secretory IgA from human colostrum induces protection against Mycobacterium tuberculosis in a murine model of progressive pulmonary infection.

TY - JOUR

T1 - Passive administration of purified secretory IgA from human colostrum induces protection against Mycobacterium tuberculosis in a murine model of progressive pulmonary infection.

AU - Alvarez, Nadine

AU - Otero, Oscar

AU - Camacho, Frank

AU - Borrero, Reinier

AU - Tirado, Yanely

AU - Puig, Alina

AU - Aguilar, Alicia

AU - Rivas, Cesar

AU - Cervantes, Axel

AU - Falero-Díaz, Gustavo

AU - Cádiz, Armando

AU - Sarmiento, María E.

AU - Norazmi, Mohd Nor

AU - Hernández-Pando, Rogelio

AU - Acosta, Armando

PY - 2013

Y1 - 2013

N2 - Immunoglobulin A is the most abundant isotype in secretions from mucosal surfaces of the gastrointestinal, respiratory and genitourinary tracts and in external secretions such as colostrum, breast milk, tears and saliva. The high concentration of human secretory IgA (hsIgA) in human colostrum strongly suggests that it should play an important role in the passive immune protection against gastrointestinal and respiratory infections. Human secretory IgA was purified from colostrum. The reactivity of hsIgA against mycobacterial antigens and its protective capacity against mycobacterial infection was evaluated. The passive administration of hsIgA reduces the pneumonic area before challenge with M. tuberculosis. The intratracheal administration of M. tuberculosis preincubated with hsIgA to mice greatly reduced the bacterial load in the lungs and diminished lung tissue injury. HsIgA purified from colostrum protects against M. tuberculosis infection in an experimental mouse model.

AB - Immunoglobulin A is the most abundant isotype in secretions from mucosal surfaces of the gastrointestinal, respiratory and genitourinary tracts and in external secretions such as colostrum, breast milk, tears and saliva. The high concentration of human secretory IgA (hsIgA) in human colostrum strongly suggests that it should play an important role in the passive immune protection against gastrointestinal and respiratory infections. Human secretory IgA was purified from colostrum. The reactivity of hsIgA against mycobacterial antigens and its protective capacity against mycobacterial infection was evaluated. The passive administration of hsIgA reduces the pneumonic area before challenge with M. tuberculosis. The intratracheal administration of M. tuberculosis preincubated with hsIgA to mice greatly reduced the bacterial load in the lungs and diminished lung tissue injury. HsIgA purified from colostrum protects against M. tuberculosis infection in an experimental mouse model.

UR - https://www.scopus.com/pages/publications/84880877009

U2 - 10.1186/1471-2172-14-s1-s3

DO - 10.1186/1471-2172-14-s1-s3

M3 - Article

C2 - 23458564

VL - 14 Suppl 1

JO - Unknown Journal

JF - Unknown Journal

ER -